Compile Data Set for Download or QSAR
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Found 14 Enz. Inhib. hit(s) with all data for entry = 50007600
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi:  48nMAssay Description:Inhibition of BCL-XL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetBcl-2-like protein 2(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi:  245nMAssay Description:Inhibition of BCL-W (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50270876(3-((E)-2-Biphenyl-3-yl-vinyl)-4'-fluoro-biphenyl-4...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of BCL-XL (unknown origin) incubated for 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50450046(CHEMBL4173974)
Affinity DataIC50:  12nMAssay Description:Inhibition of CIAP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50510872(CHEMBL4303404)
Affinity DataIC50:  39nMAssay Description:Inhibition of BRD4 bromodomain-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50450046(CHEMBL4173974)
Affinity DataIC50: <40nMAssay Description:Inhibition of XIAP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50440736(CHEMBL2431088)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of BRD4 bromodomain-1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50482750(CHEMBL1253308)
Affinity DataKd:  8.60E+3nMAssay Description:Binding affinity to HSP90 (unknown origin) by WaterLOGSY NMR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50149238(4-Hydroxybiphenyl | 4-Phenylphenol | 4-biphenylol ...)
Affinity DataKd:  6.00E+6nMAssay Description:Binding affinity to BCL-XL (unknown origin) by 15N HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | US11420968, Example ABT-199 | Venetoclax)
Affinity DataEC50:  3nMAssay Description:Inhibition of BCL-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50060993(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to BCL-XL (unknown origin) by 15N HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50482739(CHEMBL1236159)
Affinity DataKd:  250nMAssay Description:Binding affinity to HSP90 (unknown origin) by WaterLOGSY NMR analysisMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Taros Chemicals

Curated by ChEMBL
LigandPNGBDBM50270875(5,6,7,8-tetrahydro-1-naphthol | CHEMBL449132)
Affinity DataKd:  4.30E+6nMAssay Description:Binding affinity to BCL-XL (unknown origin) by 15N HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed