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Found 26 Enz. Inhib. hit(s) with all data for entry = 50010309
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537295(CHEMBL4524475)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of HIF-1alpha (786 to 826 residues) (unknown origin)/p300 (unknown origin) protein-protein interaction by ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396169(CHEMBL1337170)
Affinity DataIC50:  43nMAssay Description:Binding affinity to Cys255 residue of C-terminal Avi/FLAG-tagged HIF-1alpha (unknown origin) after 1 hr by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50484656(CHEMBL1940227)
Affinity DataIC50:  280nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396027(CHEMBL499593)
Affinity DataIC50:  540nMAssay Description:Inhibition of HIF-1alpha/p300 protein-protein interaction in human cells after 2 hrs by immunoprecipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396040(CHEMBL1823895)
Affinity DataIC50:  590nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537297(CHEMBL4542925)
Affinity DataIC50:  600nMAssay Description:Inhibition of human fluorescein-labeled HIF-1alpha (786 to 826 residues)/ human GST-fused p300 CH1 domain (323 to 423 residues) protein-protein inter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537299(CHEMBL4574165)
Affinity DataIC50:  900nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM200233(AB00053810_11 | cid_2016)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of HIF-1 dimerization in HEK293 cells after 24 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537298(CHEMBL4080730)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537291(CHEMBL4555191)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human fluorescein-labeled HIF-1alpha (786 to 826 residues)/ human GST-fused p300 CH1 domain (323 to 423 residues) protein-protein inter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537296(CHEMBL4584104)
Affinity DataIC50:  9.19E+3nMAssay Description:Binding affinity to human p300 CH1 domain (330 to 420 residues) expressed in Escherichia coli BL21(DE3) by fluorescence anisotropy competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315537(CHEMBL1089316 | chaetocin)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537303(CHEMBL4567491)
Affinity DataIC50:  2.40E+4nMAssay Description:Binding affinity to human p300 CH1 domain (330 to 420 residues) expressed in Escherichia coli BL21(DE3) by fluorescence anisotropy competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524838(CHEMBL4458726)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibition of fluorescein-labeled HIF-1alpha (786 to 826 residues) (unknown origin)/GST-fused p300 CH1 domain (323 to 423 residues) (unknown origin) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537292(CHEMBL4517800)
Affinity DataIC50:  8.30E+4nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interaction by fluorescence anisotropyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537304(CHEMBL4555830)
Affinity DataIC50:  8.90E+4nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interaction by fluorescence anisotropyMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537302(CHEMBL4545454)
Affinity DataIC50:  2.76E+5nMAssay Description:Inhibition of fluorescein-labeled HIF-1alpha (786 to 826 residues) (unknown origin)/GST-fused p300 CH1 domain (323 to 423 residues) (unknown origin) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537295(CHEMBL4524475)
Affinity DataKd:  690nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by fluorescence anisotropy competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537291(CHEMBL4555191)
Affinity DataKd:  750nMAssay Description:Binding affinity to human GST-fused p300 CH1 domain (323 to 423 residues) under hypoxic condition by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50524839(CHEMBL4466328)
Affinity DataKd:  530nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by tryptophan fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537301(CHEMBL4593074)
Affinity DataKd:  45nMAssay Description:Binding affinity to p300 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537300(CHEMBL4584063)
Affinity DataKd:  124nMAssay Description:Binding affinity to His-tagged HIF-1alpha (1 to 350 residues) (unknown origin) PAS B domain expressed in Escherichia coli BL21(DE3) by ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537293(CHEMBL4590644)
Affinity DataKd:  6.74E+3nMAssay Description:Binding affinity to p300 (unknown origin) by fluorescence anisotrophyMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537294(CHEMBL4514946)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to p300 CH1 domain (unknown origin) by tryptophan fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537297(CHEMBL4542925)
Affinity DataKd:  3.62E+3nMAssay Description:Binding affinity to human GST-fused p300 CH1 domain (323 to 423 residues) under hypoxic condition by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537301(CHEMBL4593074)
Affinity DataKd:  16nMAssay Description:Binding affinity to p300 (unknown origin) by fluorescence anisotrophyMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed