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Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50018730
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611959(CHEMBL5276024)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human heparanase incubated for 4 hrs by beta-scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611973(CHEMBL5282692)
Affinity DataIC50: 12nMAssay Description:Inhibition of HPSE (unknown origin) using fondaparinux as substrate incubated for 18 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50431651(CHEMBL2349236)
Affinity DataIC50: 17nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50093526(CHEMBL426373 | RK-682)
Affinity DataIC50: 17nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611974(CHEMBL5271999)
Affinity DataIC50: 20nMAssay Description:Inhibition of HPSE (unknown origin) using fondaparinux as substrate incubated for 18 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50104680(3-Hexadecanoyl-5-hydroxymethyl-4-methoxy-5H-furan-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611970(CHEMBL5286960)
Affinity DataIC50: 100nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50147546(2-[3-(5-Benzo[1,3]dioxol-5-yl-benzooxazol-2-yl)-4-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611966(CHEMBL5277782)
Affinity DataIC50: 200nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611968(CHEMBL5266599)
Affinity DataIC50: 230nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611965(CHEMBL5271688)
Affinity DataIC50: 250nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611969(CHEMBL5265781)
Affinity DataIC50: 290nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611961(CHEMBL5280877)
Affinity DataIC50: 400nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611962(CHEMBL5269073)
Affinity DataIC50: 400nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611963(CHEMBL5275647)
Affinity DataIC50: 400nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611975(CHEMBL5276166)
Affinity DataIC50: 416nMAssay Description:Inhibition of HPSE (unknown origin) using fondaparinux as substrate incubated for 18 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611967(CHEMBL5281679)
Affinity DataIC50: 500nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50378647(PI-88 | CHEMBL1627122)
Affinity DataIC50: 980nMAssay Description:Inhibition of human HPSE expressed in human HREC cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50405558(CHEMBL3347523)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human HPSE assessed as residual amount of heparin using porcine heparin as substrate preincubated for 5 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611980(CHEMBL5288048)
Affinity DataIC50: 3.55E+3nMAssay Description:Inhibition of human recombinant heparanase preincubated for 10 mins followed by Bio-HS-Eu(K) substrate addition and measured after 150 mins by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611972(CHEMBL5266899)
Affinity DataIC50: 4.47E+3nMAssay Description:Inhibition of human HPSE using fluorescein isothiocyanate-HS as substrate incubated for 3 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611976(CHEMBL5269056)
Affinity DataIC50: 4.82E+3nMAssay Description:Inhibition of HPSE (unknown origin) using fondaparinux as substrate incubated for 18 hrs by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50147526(2-(3-Benzooxazol-2-yl-phenyl)-1,3-dioxo-indan-5-ca...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50147543(2-(5-Benzooxazol-2-yl-2-methoxy-phenyl)-1,3-dioxo-...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611960(CHEMBL5275830)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HPSE assessed as residual amount of heparin using porcine heparin as substrate preincubated for 5 mins followed by substrate addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611964(CHEMBL5288229)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HPSE incubated for 2 hrs using TMB peroxidase as substrate by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611958(CHEMBL5277725)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of HPSE (unknown origin) using Biotin-heparan sulfate-Eu cryptate as substrate incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611977(CHEMBL5288522)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of HPSE (unknown origin) assessed as decrease in radioactivity using [35S] heparan sulfate as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611978(CHEMBL5268401)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of HPSE (unknown origin) assessed as decrease in radioactivity using [35S] heparan sulfate as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611979(CHEMBL5268596)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of HPSE (unknown origin) assessed as decrease in radioactivity using [35S] heparan sulfate as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Mouse)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50595401(CHEMBL5175115)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of heparanase in mouse B16-BL6 cells using [3H]acetyl HS as substrate incubated for 3 hrs by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of HPSE (unknown origin) assessed as decrease in radioactivity using [35S] heparan sulfate as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of HPSE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHeparanase(Human)
Guangzhou University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50611971(CHEMBL5280887)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of human HPSE using fluorescein isothiocyanate-HS as substrate incubated for 3 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed