Compile Data Set for Download or QSAR
Report error Found 94 Enz. Inhib. hit(s) with all data for entry = 50013370
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565178(CHEMBL4460742)
Affinity DataKi:  0.0270nMAssay Description:Displacement of [125I]EYF from human NPFFR2 expressed in CHO cells by gamma-counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565179(CHEMBL4782986)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I](Tyr)NPF from rat NPFFR1 expressed in rat PC12 cells incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037557(2-{[1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4...)
Affinity DataKd:  0.210nMAssay Description:Binding affinity to human NPFFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565182(CHEMBL4797394)
Affinity DataEC50:  0.340nMAssay Description:Agonist activity at human delta-opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037557(2-{[1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4...)
Affinity DataKd:  0.370nMAssay Description:Binding affinity to human NPFFR2 expressed in green monkey COS-7 cell membranes by [125I]-1DMeNPFF radioligand based saturation binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50029188(CHEMBL2165920)
Affinity DataKi:  0.590nMAssay Description:Displacement of [125I]YVP from human NPFFR1 expressed in CHO cells by gamma-counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565183(CHEMBL4790994)
Affinity DataEC50:  0.780nMAssay Description:Agonist activity at human delta-opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565194(CHEMBL4793841)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-FFRF-NH2 from human NPFFR1 expressed in CHO cell membrane by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037557(2-{[1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4...)
Affinity DataKd:  1.10nMAssay Description:Binding affinity to human NPFFR1 expressed in green monkey COS-7 cell membranes by [125I]-1DMeNPFF radioligand based saturation binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50029188(CHEMBL2165920)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]YVP from human NPFFR1 expressed in HEK293 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565189(CHEMBL4779743)
Affinity DataKi:  1.40nMAssay Description:Displacement of TAMRA-NPFF from human NPFFR2 expressed in CHO-K1 cells preincubated for 15 mins followed by GTPgammaS addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037567(2-[(Pyrrolidine-2-carbonyl)-amino]-pentanedioic ac...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]-1DMeNPFF from rat NPFFR1 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037567(2-[(Pyrrolidine-2-carbonyl)-amino]-pentanedioic ac...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]-1DMeNPFF from rat NPFFR2 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037567(2-[(Pyrrolidine-2-carbonyl)-amino]-pentanedioic ac...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]YVP from human NPFFR1 expressed in HEK293 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565190(CHEMBL4800299)
Affinity DataKi:  2.20nMAssay Description:Displacement of TAMRA-NPFF from human NPFFR2 expressed in CHO-K1 cells preincubated for 15 mins followed by GTPgammaS addition and measured after 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565178(CHEMBL4460742)
Affinity DataKi:  2.90nMAssay Description:Displacement of [125I]YVP from human NPFFR1 expressed in CHO cells by gamma-counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037567(2-[(Pyrrolidine-2-carbonyl)-amino]-pentanedioic ac...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]-1DMeNPFF from human NPFFR2 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037557(2-{[1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4...)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at human NPFFR2 expressed in CHO cells assessed as inhibition of forskolin-induced intracellular cyclic cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565181(CHEMBL4783555)
Affinity DataEC50:  4.40nMAssay Description:Agonist activity at kappa opioid receptor (unknown origin) expressed in HEK-293A cells assessed as inhibition of forskolin-induced cAMP accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50034115(1N-[1-carbamoyl-2-phenyl-(1S)-ethyl]-5-amino(imino...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [125I]EYF from human NPFFR2 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565185(CHEMBL4777535)
Affinity DataKi:  7nMAssay Description:Binding affinity to rat NPFFR1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037567(2-[(Pyrrolidine-2-carbonyl)-amino]-pentanedioic ac...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [125I]-1DMeNPFF from human NPFFR1 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565182(CHEMBL4797394)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human NPFFR2 expressed in CHO cells by [35S]-GTP S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565182(CHEMBL4797394)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human mu-opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50442584(CHEMBL2440929)
Affinity DataKi:  12nMAssay Description:Displacement of [125I]YVP from human NPFFR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565185(CHEMBL4777535)
Affinity DataKi:  13nMAssay Description:Binding affinity to human NPFFR1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565183(CHEMBL4790994)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human mu-opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565180(CHEMBL4776204)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human NPFFR1 expressed in CHO-K1 cells assessed as reversal of agonist-induced inhibition of forskolin-stimulated cAMP accumul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50029188(CHEMBL2165920)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]EYF from human NPFFR2 expressed in CHO cells by gamma-counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565184(CHEMBL4799458)
Affinity DataKi:  24nMAssay Description:Binding affinity to human NPFFR1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565184(CHEMBL4799458)
Affinity DataKi:  25nMAssay Description:Binding affinity to rat NPFFR1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037573((S)-2-[((S)-Pyrrolidine-2-carbonyl)-amino]-pentane...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]-1DMeNPFF from human NPFFR2 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037573((S)-2-[((S)-Pyrrolidine-2-carbonyl)-amino]-pentane...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]-1DMeNPFF from rat NPFFR1 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037573((S)-2-[((S)-Pyrrolidine-2-carbonyl)-amino]-pentane...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]-1DMeNPFF from rat NPFFR2 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565181(CHEMBL4783555)
Affinity DataEC50:  25nMAssay Description:Agonist activity at NPFFR2 (unknown origin) expressed in HEK-293A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565194(CHEMBL4793841)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]-FFRF-NH2 from human NPFFR2 expressed in CHO cell membrane by Topcount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50037573((S)-2-[((S)-Pyrrolidine-2-carbonyl)-amino]-pentane...)
Affinity DataKi:  40nMAssay Description:Displacement of [125I]-1DMeNPFF from human NPFFR1 expressed in HEK293 cells incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50336912(Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamo...)
Affinity DataKi:  58nMAssay Description:Displacement of [125I]YVP from human NPFFR1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50336912(Adamantane-1-carboxylic acid [(S)-1-((S)-1-carbamo...)
Affinity DataKi:  75nMAssay Description:Displacement of [125I]Tyr-NPFF from human NPFFR2 expressed in green monkey Cos-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565182(CHEMBL4797394)
Affinity DataEC50:  85nMAssay Description:Agonist activity at human NPFFR1 expressed in CHO cells by [35S]-GTP S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565185(CHEMBL4777535)
Affinity DataKi:  91nMAssay Description:Binding affinity to human NPFFR2 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565183(CHEMBL4790994)
Affinity DataEC50:  95nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565188(CHEMBL4784123)
Affinity DataKi:  100nMAssay Description:Displacement of 125I-NPFF from human NPFFR1 incubated for 2 hrs by TopCount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565186(CHEMBL4785076)
Affinity DataEC50:  100nMAssay Description:Agonist activity at NPFFR2 (unknown origin) expressed in mouse NIH3T3 cells by receptor selection and amplification technology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565179(CHEMBL4782986)
Affinity DataKi:  101nMAssay Description:Displacement of [125I](Tyr)NPF from rat NPFFR1 expressed in rat PC12 cells incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565182(CHEMBL4797394)
Affinity DataEC50:  108nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565184(CHEMBL4799458)
Affinity DataKi:  123nMAssay Description:Binding affinity to human NPFFR2 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565188(CHEMBL4784123)
Affinity DataKi:  126nMAssay Description:Displacement of 125I-NPFF from human NPFFR2 incubated for 2 hrs by TopCount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565183(CHEMBL4790994)
Affinity DataEC50:  157nMAssay Description:Agonist activity at human NPFFR2 expressed in CHO cells by [35S]-GTP S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetNeuropeptide FF receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50565191(CHEMBL4778746)
Affinity DataKi:  172nMAssay Description:Displacement of [3H]-FFRF-NH2 from human FLAG-tagged NPFFR1 expressed in CHO cell membrane incubated for 30 mins by Topcount scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
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