Compile Data Set for Download or QSAR
maximum 50k data
Found 61 Enz. Inhib. hit(s) with all data for entry = 50015582
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to PLK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
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TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587680(CHEMBL5182271)
Affinity DataIC50:  1nMAssay Description:Inhibition of human IGF1R expressed in mouse IGF1R knockout MEF cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInsulin receptor(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587680(CHEMBL5182271)
Affinity DataIC50:  1nMAssay Description:Inhibition of human InsR expressed in mouse IGF1R knockout MEF cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587681(CHEMBL5176650)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50:  3nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type ALK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587677(CHEMBL5173501)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50468574(CHEMBL4116008 | US11414410, Example 100)
Affinity DataIC50:  4nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587683(CHEMBL5196626)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK9 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK7 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK4 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 3(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK3 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK1 (unknown origin) expressed in baculovirus-infected Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50:  5nMAssay Description:Inhibition of human NUAK1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM17051(BX-795 | BX-795, 3 | N-(3-{[5-iodo-4-({3-[(thiophe...)
Affinity DataIC50:  5nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM86615(Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 2...)
Affinity DataIC50:  6nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587672(CHEMBL5192992)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587682(CHEMBL5204647)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50511926(CHEMBL4442620)
Affinity DataIC50: <10nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50:  11nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50:  12nMAssay Description:Inhibition of GST fused recombinant SIK2 in HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser329 incubated for 1 hr in presence of ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587673(CHEMBL5175737)
Affinity DataIC50:  15nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587670(CHEMBL5202161)
Affinity DataIC50:  17nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50383274(CHEMBL1229592 | US10167264, WZ4002 | US9670213, WZ...)
Affinity DataIC50:  25nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50:  26nMAssay Description:Inhibition of PDGFRb (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50447512(CHEMBL3115681)
Affinity DataIC50:  26nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50:  30nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587674(CHEMBL1643963)
Affinity DataIC50:  33nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587684(CHEMBL5169640)
Affinity DataIC50:  35nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase SIK3(Homo sapiens)
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50:  43nMAssay Description:Inhibition of GST fused recombinant SIK3 in HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser370 incubated for 1 hr in presence of ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  47nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  48nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50:  54nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50524300(LY2606368 | Prexasertib | US11564920, Example Prex...)
Affinity DataIC50:  64nMAssay Description:Inhibition of NUAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587676(CHEMBL5195181)
Affinity DataIC50:  67nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 2(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587675(CHEMBL4303523)
Affinity DataIC50:  100nMAssay Description:Inhibition of N-terminal GST-tagged human NUAK2 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP by cerenko...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587671(CHEMBL4303250)
Affinity DataIC50:  100nMAssay Description:Inhibition of N-terminal GST-tagged wild type human NUAK1 expressed in Escherichia coli DH5alpha incubated for 30 mins in presence of gamma-[32P]ATP ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase SIK1(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50:  110nMAssay Description:Inhibition of GST fused recombinant SIK1 in HEK293 cells assessed as effect on CRTC3 phosphorylation at Ser162 incubated for 1 hr in presence of ATP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAurora kinase C(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587669(CHEMBL5190521)
Affinity DataIC50:  120nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 2(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587679(CHEMBL5199998)
Affinity DataIC50:  120nMAssay Description:Inhibition of NUAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNUAK family SNF1-like kinase 2(Homo sapiens (Human))
University Of Science And Technology (Ust)

Curated by ChEMBL
LigandPNGBDBM50587685(CHEMBL5202966)
Affinity DataIC50:  126nMAssay Description:Inhibition of NUAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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