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Target
NUAK family SNF1-like kinase 1
Ligand
BDBM17051
Substrate
n/a
Meas. Tech.
ChEMBL_2184485 (CHEMBL5096567)
IC50
5.0±n/a nM
Citation
 Faisal, M; Kim, JH; Yoo, KH; Roh, EJ; Hong, SS; Lee, SH Development and Therapeutic Potential of NUAKs Inhibitors. J Med Chem 64:2-25 (2021) [PubMed] 
Target
Name:
NUAK family SNF1-like kinase 1
Synonyms:
ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1
Type:
PROTEIN
Mol. Mass.:
74326.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451343
Residue:
661
Sequence:
MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDIANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEVMLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYSSPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPALVSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRSCVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKLN
  
Inhibitor
Name:
BDBM17051
Synonyms:
BX-795 | BX-795, 3 | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide | N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl]amino}pyrimidin-2-yl)amino]phenyl}pyrrolidine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C23H26IN7O2S
Mol. Mass.:
591.468
SMILES:
Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c1cccs1
Structure:
Search PDB for entries with ligand similarity: