Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50011504
TargetTyrosine-protein kinase JAK3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548083(CHEMBL4748313 | US11993603, Example 1)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human JAK3 expressed in baculovirus expression system using TK-substrate-biotin as substrate preincubated for 5 mins followed by ATP an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataKi:  1.40nMAssay Description:Inhibition of mTOR (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548080(CHEMBL4763913)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548085(CHEMBL4792279)
Affinity DataIC50: 186nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3K-alpha (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3K-beta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3K-delta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataIC50: 200nMAssay Description:Inhibition of PI3K-gamma (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548081(CHEMBL4752986)
Affinity DataIC50: 220nMAssay Description:Inhibition of N-terminal GST-tagged human VEGFR2 (805 to 1356 residues) expressed in a baculovirus infected Sf9 insect cell incubated for 45 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548085(CHEMBL4792279)
Affinity DataIC50: 254nMAssay Description:Inhibition of human HER2 using Biotin- FLT3 (Tyr589) peptide as substrate preincubated for 5 mins followed by ATP/substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548084(CHEMBL4786003)
Affinity DataIC50: 4.18E+3nMAssay Description:Inhibition of EGFR (unknown origin) by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548087(CHEMBL4796913)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells using histone H1 as substrate in presence of [gamma3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548086(CHEMBL4743559)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf21 insect cells using histone H1 as substrate in presence of [gamma3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of Edinburgh

Curated by ChEMBL
LigandPNGBDBM50548082(CHEMBL4761353)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human AXL using poly [Glu, Tyr] 4:1 as substrate in presence of [gamma33P]-ATP by radioisotope-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed