Compile Data Set for Download or QSAR
Report error Found 52 Enz. Inhib. hit(s) with all data for entry = 50017516
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 429328BDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataKi:  70nMAssay Description:Non-covalent inhibition to SARS-CoV-2 -Mpro assessed as inhibition constant by native mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602444BDBM50602444(CHEMBL5206501)
Affinity DataIC50: 200nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602445BDBM50602445(CHEMBL5207542 | US20240083885, Compound Jun9-4-4)
Affinity DataIC50: 280nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602446BDBM50602446(CHEMBL5178131 | US20240083885, Compound Jun8-66-1)
Affinity DataIC50: 510nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602447BDBM50602447(CHEMBL5169554 | US20240083885, Compound Jun8-91-4)
Affinity DataIC50: 560nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602448BDBM50602448(CHEMBL5186431 | US20240083885, Compound Jun8-76-3)
Affinity DataIC50: 660nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602449BDBM50602449(CHEMBL5201613 | US20240083885, Compound Jun9-5-2)
Affinity DataIC50: 670nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602450BDBM50602450(CHEMBL5172431 | US20240083885, Compound Jun8-76-4)
Affinity DataIC50: 810nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602451BDBM50602451(CHEMBL5189062 | US20240083885, Compound Jun8-76-5)
Affinity DataIC50: 940nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602452BDBM50602452(CHEMBL5208393 | US20240083885, Compound Jun8-90-3)
Affinity DataIC50: 960nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602453BDBM50602453(CHEMBL5179577 | US20240083885, Compound Jun9-12-2)
Affinity DataIC50: 1.05E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602454BDBM50602454(CHEMBL5204664 | US20240083885, Compound Jun9-5-3)
Affinity DataIC50: 1.48E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602455BDBM50602455(CHEMBL5175491 | US20240083885, Compound Jun9-6-4)
Affinity DataIC50: 1.81E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602456BDBM50602456(CHEMBL5198265 | US20240083885, Compound Jun8-75-2)
Affinity DataIC50: 1.97E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602457BDBM50602457(CHEMBL5195867)
Affinity DataIC50: 2.14E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602444BDBM50602444(CHEMBL5206501)
Affinity DataKi:  2.29E+3nMAssay Description:Non-covalent inhibition to SARS-CoV-2 -Mpro assessed as inhibition constant by native mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602458BDBM50602458(CHEMBL5180821)
Affinity DataIC50: 2.39E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602459BDBM50602459(CHEMBL5196047 | US20240083885, Compound Jun8-92-1)
Affinity DataIC50: 2.47E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602460BDBM50602460(CHEMBL5193830 | US20240083885, Compound Jun8-88-2)
Affinity DataIC50: 2.51E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602461BDBM50602461(CHEMBL5182370 | US20240083885, Compound Jun8-91-5)
Affinity DataIC50: 2.54E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602462BDBM50602462(CHEMBL5176045 | US20240083885, Compound Jun9-3-3)
Affinity DataIC50: 2.68E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602463BDBM50602463(CHEMBL5193986 | US20240083885, Compound Jun8-58-2)
Affinity DataIC50: 3.86E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602464BDBM50602464(CHEMBL5170916 | US20240083885, Compound Jun9-3-2)
Affinity DataIC50: 4.10E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 429456BDBM429456(med.21724, Compound 128 | acs.jmedchem.1c00409_ST....)
Affinity DataIC50: 4.93E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602465BDBM50602465(CHEMBL5190815 | US20240083885, Compound Jun8-92-2)
Affinity DataIC50: 4.97E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602466BDBM50602466(CHEMBL5188059 | US20240083885, Compound Jun8-88-1)
Affinity DataIC50: 5.37E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602467BDBM50602467(CHEMBL5171513 | US20240083885, Compound Jun8-97-1)
Affinity DataIC50: 5.46E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602468BDBM50602468(CHEMBL5170231 | US20240083885, Compound Jun8-56-1)
Affinity DataIC50: 5.70E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602469BDBM50602469(CHEMBL5179593 | US20240083885, Compound Jun9-4-2)
Affinity DataIC50: 5.82E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCalpain-1 catalytic subunit(Human)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602444BDBM50602444(CHEMBL5206501)
Affinity DataIC50: 6.00E+3nMAssay Description:Non-covalent inhibition of Calpain 1 (unknown origin) incubated for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602470BDBM50602470(CHEMBL5171325)
Affinity DataIC50: 7.27E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602471BDBM50602471(CHEMBL5171462 | US20240083885, Compound Jun9-88-4)
Affinity DataIC50: 7.49E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602472BDBM50602472(CHEMBL5188623 | US20240083885, Compound Jun9-88-3)
Affinity DataIC50: 7.81E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602473BDBM50602473(CHEMBL5192910 | US20240083885, Compound Jun8-74-1)
Affinity DataIC50: 8.13E+3nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602444BDBM50602444(CHEMBL5206501)
Affinity DataKd:  9.43E+3nMAssay Description:Stabilization in SARS-CoV-2 MPro assessed as binding constant incubated for 30 mins in presence of DTT by thermal shift binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProcathepsin L(Human)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602444BDBM50602444(CHEMBL5206501)
Affinity DataIC50: 1.05E+4nMAssay Description:Non-covalent inhibition of Cathepsin L (unknown origin) incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 429328BDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 1.10E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602474BDBM50602474(CHEMBL5176329)
Affinity DataIC50: 1.21E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 496109BDBM496109(ALP-POS-02c6a514-57 | CVD-0013887 | US20240083885,...)
Affinity DataIC50: 1.32E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602482BDBM50602482(CHEMBL5191806)
Affinity DataIC50: 2.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602475BDBM50602475(CHEMBL5207030)
Affinity DataIC50: 2.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602477BDBM50602477(CHEMBL5178977 | US20240083885, Compound Jun8-50-3)
Affinity DataIC50: 2.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602476BDBM50602476(CHEMBL5189716 | US20240083885, Compound Jun8-50-4)
Affinity DataIC50: 2.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602479BDBM50602479(CHEMBL3605708 | US20240083885, Compound Jun8-58-3)
Affinity DataIC50: 2.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602478BDBM50602478(CHEMBL2311738 | US20240083885, Compound Jun8-59-2)
Affinity DataIC50: 2.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602480BDBM50602480(CHEMBL5170981 | US20240083885, Compound Jun9-5-4)
Affinity DataIC50: 2.19E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50602481BDBM50602481(CHEMBL5195155 | US20240083885, Compound Jun8-92-4)
Affinity DataIC50: 3.51E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 419133BDBM419133(GC376 | BDBM429386 | US12180156, BS of GC373)
Affinity DataIC50: 5.00E+4nMAssay Description:Covalent inhibition of SARS-Cov-2 PLpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTrypsin(Human)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 419133BDBM419133(GC376 | BDBM429386 | US12180156, BS of GC373)
Affinity DataIC50: 5.00E+4nMAssay Description:Covalent inhibition of trypsin (unknown origin) incubated for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
The University of Arizona

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 429328BDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 6.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 PLpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
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