Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50018641
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50610581(CHEMBL5281728)
Affinity DataEC50:  23nMAssay Description:Displacement of fluorescent-labeled BID-BH3 peptide from His-tagged BFL-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 31nMAssay Description:Inhibition of Bcl-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 76nMAssay Description:Inhibition of Bcl-xl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 122nMAssay Description:Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50366237(GAMBOGIC ACID)
Affinity DataIC50: 122nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 200nMAssay Description:Inhibition of Mcl-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50610578(CHEMBL5283854)
Affinity DataIC50: 264nMAssay Description:Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 310nMAssay Description:Inhibition of Bcl-xl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 320nMAssay Description:Inhibition of Bcl-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM380468(US9926306, ID 183-21)
Affinity DataIC50: 365nMAssay Description:Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50610577(CHEMBL5283368)
Affinity DataKi:  400nMAssay Description:Inhibition of Bfl-1/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM31810(Apogossypol derivative, 8r)
Affinity DataIC50: 620nMAssay Description:Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-like protein 10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50366237(GAMBOGIC ACID)
Affinity DataIC50: 660nMAssay Description:Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant Bcl-B (unknown origin) by fluorescence polarization-based competitive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50610577(CHEMBL5283368)
Affinity DataIC50: 800nMAssay Description:Inhibition of Bfl-1/Bim (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50366237(GAMBOGIC ACID)
Affinity DataIC50: 1.06E+3nMAssay Description:Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant BFL-1 (unknown origin) by fluorescence polarization-based competitive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50330250(5,5'-Dibenzyl-6,6',7,7'-tetrahydroxy-3,3'-dimethyl...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50610579(CHEMBL5282751)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50610577(CHEMBL5283368)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Bfl-1/Bim (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50366237(GAMBOGIC ACID)
Affinity DataIC50: 1.47E+3nMAssay Description:Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant Bcl-xl (unknown origin) by fluorescence polarization-based competitive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50610580(CHEMBL5267837)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Bfl-1 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50366237(GAMBOGIC ACID)
Affinity DataIC50: 2.02E+3nMAssay Description:Displacement of fluorescein tagged BID BH3 peptide from GST-tagged recombinant Bcl-W (unknown origin) by fluorescence polarization-based competitive ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604877(CHEMBL5189912)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Bfl-1/Bim (unknown origin) incubated for 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of C-terminal GST-tagged Bfl-1 (unknown origin) incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of C-terminal GST-tagged Bfl-1 (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604877(CHEMBL5189912)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of Bfl-1/Bim (unknown origin) assessed as inhibition constant by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of C-terminal GST-tagged Bfl-1 (unknown origin) incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50604877(CHEMBL5189912)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of Bfl-1/Bim (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed