Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50018395
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50436682(CHEMBL2396674)
Affinity DataKi:  0.440nMAssay Description:Binding affinity to human recombinant his-tagged MDM2 assessed as inhibition constant by fluorescence polarization based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50607976(CHEMBL5271815)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine chloride as substrate incubated for 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50251393(Rhynchophylline | CHEMBL519266)
Affinity DataEC50:  17nMAssay Description:Agonist activity at 5HT1A (unknown origin) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50607978(CHEMBL5276750)
Affinity DataIC50: 115nMAssay Description:Inhibition of human BACE1 (1 to 454 residues) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 350nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetAcetylcholinesterase(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50607976(CHEMBL5271815)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 20 mins by DTNB reagent based Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetCholinesterase(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM10404(galantamine | (1S,12S,14R)-9-methoxy-4-methyl-11-o...)
Affinity DataIC50: 1.86E+4nMAssay Description:Inhibition of BChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50390992(GNF-Pf-3462 | CHEMBL601773)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMelatonin receptor type 1A(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM23416((+)-Catechin | CHEMBL311498 | (2R,3S)-2-(3,4-dihyd...)
Affinity DataIC50: 2.58E+4nMAssay Description:Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMelatonin receptor type 1B(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM23416((+)-Catechin | CHEMBL311498 | (2R,3S)-2-(3,4-dihyd...)
Affinity DataIC50: 4.73E+4nMAssay Description:Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMelatonin receptor type 1A(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50607977(CHEBI:68144 | CHEMBL1814389)
Affinity DataIC50: 1.56E+5nMAssay Description:Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMelatonin receptor type 1B(Human)
Rmit University

Curated by ChEMBL
LigandPNGBDBM50607977(CHEBI:68144 | CHEMBL1814389)
Affinity DataIC50: 2.09E+5nMAssay Description:Agonist activity at human melatonin MT2 receptor stably expressing in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed