Compile Data Set for Download or QSAR
Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50018768
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50095105(4-{2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-[1,...)
Affinity DataKi:  0.0100nMAssay Description:Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50052278(5-[(2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2...)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50049469(5-[(2S,3S)-2-(3,5-Bis-trifluoromethyl-benzyloxy)-3...)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50220136(CHEMBL1471 | 5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluo...)
Affinity DataIC50: 0.0900nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612261(CHEMBL5290533)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50213021(CHEBI:63621 | Fortovase | Invirase | Ro-31-8959 | ...)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612272(CHEMBL5277648)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50276653((S)-2-(4-(((S)-1-((R)-3-amino-4-(2,5-difluoropheny...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of recombinant human dipeptidyl peptidase 4 using Gly-Pro-AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50103773((4-Fluoro-naphthalen-1-yl)-(4-{2-[4-(4-methoxy-ben...)
Affinity DataKi:  0.510nMAssay Description:Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50049468((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50: 0.870nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50342885((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of human SGLT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612254(CHEMBL1945780)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of dopamine transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612258(CHEMBL5284869)
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50213021(CHEBI:63621 | Fortovase | Invirase | Ro-31-8959 | ...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of HIV-1 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612259(CHEMBL5285318)
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50489369(GRL-0519 | CHEMBL1232930)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612254(CHEMBL1945780)
Affinity DataIC50: 2nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human SGLT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612273(BALOXAVIR | Baloxavir | S-033447 | US12161646, Exa...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Influenza A virus CENMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent dopamine transporter(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612255(CHEMBL5271116)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of dopamine transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSomatostatin receptor type 2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612264(CHEMBL5276641)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human SSTR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612255(CHEMBL5271116)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Rat)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50051903(2-[1,3]Dioxolan-2-yl-4,5-diphenyl-1H-imidazole | C...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of ACAT in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50095103(4-{2-[4-(Benzo[1,3]dioxole-5-sulfonyl)-phenyl]-tet...)
Affinity DataKi:  5nMAssay Description:Antagonist activity at muscarinic M2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSomatostatin receptor type 2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50075272((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-2-[3-(3...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of human SSTR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50059717(4-Furan-3-yl-7-[6-(4-hydroxy-tetrahydro-pyran-4-yl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human 5-LO expressed in Sf9 cells by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM568((3aR,4S,6aR)-hexahydro-2H-cyclopenta[b]furan-4-yl ...)
Affinity DataIC50: 17nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSomatostatin receptor type 2(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50075284((2R,3S)-N-(5-Amino-[1,3]dioxan-2-ylmethyl)-3-(1H-i...)
Affinity DataKi:  18nMAssay Description:Inhibition of human SSTR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50059715(4-Furan-3-yl-7-[6-(3-hydroxy-6,8-dioxa-bicyclo[3.2...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human 5-LO expressed in Sf9 cells by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612260(CHEMBL5286807)
Affinity DataIC50: 24nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612257(CHEMBL5291459)
Affinity DataIC50: 28nMAssay Description:Displacement of [125I]-labeled SP from human NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612252(CHEMBL5276872)
Affinity DataKi:  38nMAssay Description:Inhibition of Hepatitis C virus NS4A-NS3 protease by continuous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612253(CHEMBL5288126)
Affinity DataKi:  38nMAssay Description:Inhibition of Hepatitis C virus NS4A-NS3 protease by continuous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50051901(1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)
Affinity DataIC50: 40nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612265(CHEMBL5290093)
Affinity DataIC50: 44nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612266(CHEMBL5268786)
Affinity DataIC50: 50nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50: 56nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612269(CHEMBL5284960)
Affinity DataIC50: 60nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Mouse)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50551012(CHEMBL4759441)
Affinity DataIC50: 63nMAssay Description:Inhibition of mouse brain FAAHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612270(CHEMBL5275490)
Affinity DataIC50: 70nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Rat)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612271(CHEMBL5290994)
Affinity DataIC50: 75nMAssay Description:Inhibition of ACAT in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612263(CHEMBL5287571)
Affinity DataIC50: 100nMAssay Description:Inhibition of amyloid beta (1 to 42 ) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Rat)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50051902(4,5-Diphenyl-2-(tetrahydro-pyran-2-yl)-1H-imidazol...)
Affinity DataIC50: 110nMAssay Description:Inhibition of ACAT in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Rat)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50051905(2-[1,3]Dioxan-2-yl-4,5-diphenyl-1H-imidazole | CHE...)
Affinity DataIC50: 110nMAssay Description:Inhibition of ACAT in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50053540(4-Furan-3-yl-7-[3-(3-hydroxy-6,8-dioxa-bicyclo[3.2...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human 5-LO expressed in Sf9 cells by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50612267(CHEMBL5267175)
Affinity DataIC50: 160nMAssay Description:Inhibition of ACAT in human THP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50053548(L-702-539 | 4-Furan-3-yl-7-[3-(3-hydroxy-6,8-dioxa...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human 5-LO expressed in Sf9 cells by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM567((3R,3aR,6aS)-hexahydro-2H-cyclopenta[b]furan-3-yl ...)
Affinity DataIC50: 190nMAssay Description:Inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50053519(7-[3-(3-Hydroxy-6,8-dioxa-bicyclo[3.2.1]oct-3-yl)-...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human 5-LO expressed in Sf9 cells by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSterol O-acyltransferase 1(Rat)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50051887(cid_10232 | CHEMBL34173 | 2,4,5-triphenyl-1H-imida...)
Affinity DataIC50: 260nMAssay Description:Inhibition of ACAT in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
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