Compile Data Set for Download or QSAR
Report error Found 107 Enz. Inhib. hit(s) with all data for entry = 50013515
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataKi:  0.470nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataIC50: 1.30nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataIC50: 1.90nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566910(CHEMBL4870569)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 3.20nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 3.20nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566901(CHEMBL4865464)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566913(CHEMBL4857474)
Affinity DataKi:  19nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataKi:  32nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566900(CHEMBL4862802)
Affinity DataIC50: 35nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566907(CHEMBL4851236)
Affinity DataIC50: 36nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566910(CHEMBL4870569)
Affinity DataIC50: 37nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566901(CHEMBL4865464)
Affinity DataIC50: 47nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566906(CHEMBL4867038)
Affinity DataIC50: 49nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 57nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50072064(CHEMBL416146 | 5-Chloro-3-(4-methanesulfonyl-pheny...)
Affinity DataKi:  69nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataIC50: 78nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566900(CHEMBL4862802)
Affinity DataKi:  114nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566910(CHEMBL4870569)
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataIC50: 130nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataIC50: 130nMAssay Description:Inhibition of COX1 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566910(CHEMBL4870569)
Affinity DataIC50: 146nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataIC50: 160nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566909(CHEMBL4873184)
Affinity DataIC50: 210nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566901(CHEMBL4865464)
Affinity DataIC50: 226nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566913(CHEMBL4857474)
Affinity DataIC50: 230nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataIC50: 345nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566901(CHEMBL4865464)
Affinity DataIC50: 346nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50078590(1-[3-(4-Methanesulfonyl-phenyl)-5-trifluoromethyl-...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 410nMAssay Description:Inhibition of COX1 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50072064(CHEMBL416146 | 5-Chloro-3-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM11639(Celecoxib | CLX | Celebrex | 4-[5-(4-methylphenyl)...)
Affinity DataIC50: 440nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566913(CHEMBL4857474)
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566906(CHEMBL4867038)
Affinity DataIC50: 511nMAssay Description:Inhibition of COX1 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566905(CHEMBL4877517)
Affinity DataIC50: 540nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50072064(CHEMBL416146 | 5-Chloro-3-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 560nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566900(CHEMBL4862802)
Affinity DataIC50: 600nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50072064(CHEMBL416146 | 5-Chloro-3-(4-methanesulfonyl-pheny...)
Affinity DataIC50: 611nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataIC50: 742nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566900(CHEMBL4862802)
Affinity DataIC50: 840nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataIC50: 877nMAssay Description:Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566896(CHEMBL4848190)
Affinity DataIC50: 950nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566904(CHEMBL4856126)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566908(CHEMBL4879174)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50078590(1-[3-(4-Methanesulfonyl-phenyl)-5-trifluoromethyl-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50566895(CHEMBL4866615)
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
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