Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50015180
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583509(CHEMBL5093928)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583519(SOTICLESTAT | Soticlestat | OV-935 | OV935 | TAK-9...)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583501(CHEMBL4594072)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583512(CHEMBL4532699)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583515(CHEMBL4527933)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583517(CHEMBL4538165)
Affinity DataIC50: 12nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583518(CHEMBL5083867)
Affinity DataIC50: 12nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583508(CHEMBL5076011)
Affinity DataIC50: 14nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583507(CHEMBL5082831)
Affinity DataIC50: 16nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583514(CHEMBL4580834)
Affinity DataIC50: 24nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583506(CHEMBL5087082)
Affinity DataIC50: 28nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583503(CHEMBL4561003)
Affinity DataIC50: 44nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583511(CHEMBL5083692)
Affinity DataIC50: 48nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583499(CHEMBL4555625)
Affinity DataIC50: 52nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583505(CHEMBL5094350)
Affinity DataIC50: 58nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583516(CHEMBL5082660)
Affinity DataIC50: 65nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583510(CHEMBL5080231)
Affinity DataIC50: 68nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583504(CHEMBL5085981)
Affinity DataIC50: 72nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583500(CHEMBL5074135)
Affinity DataIC50: 74nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583502(CHEMBL5086659)
Affinity DataIC50: 160nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataIC50: 430nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583498(CHEMBL5074319)
Affinity DataIC50: 950nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCholesterol 24-hydroxylase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50583513(CHEMBL5079582)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of CH24H expressing human 293-F cells for 15 minutes using [14C] cholesterol as substrate and measured after 5 hrs by trypan blue staining...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed