Compile Data Set for Download or QSAR
Report error Found 77 Enz. Inhib. hit(s) with all data for entry = 50018682
LigandPNGBDBM50611368(CHEMBL5274907)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of PI3Kdelta (unknown origin) at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611354(CHEMBL5271030)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611354(CHEMBL5271030)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild type BTK (unknown origin) in presence of 1 uM ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50611369(CHEMBL5283460)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant FGFR2 in the presence of ATP at 0.8 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50258974(CHEMBL4090601)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611355(Zipalertinib | Cln 081 | Cln-081 | CLN-081 | CLN08...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611354(CHEMBL5271030)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human recombinant FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50521316(CHEMBL4560385)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Yes(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611365(CHEMBL5268244)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant FGFR2 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 4(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611354(CHEMBL5271030)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant FGFR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611365(CHEMBL5268244)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant FGFR3 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50258975(CHEMBL4094959)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of EGFR T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50258976(CHEMBL4095447)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of EGFR T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611356(CHEMBL5268867)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611365(CHEMBL5268244)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Yes(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611364(CHEMBL5280361)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611356(CHEMBL5268867)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611360(CHEMBL5276925)
Affinity DataIC50: 3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50504103(CHEMBL4463714)
Affinity DataIC50: 3nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 3nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged LCK (62 to 509 residues) (unknown origin) expressed in Sf9 insect cells at 10 uM using poly (Glu, Tyr) 4:1 as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant FGFR1 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611362(CHEMBL5276538)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant GST-tagged RET (unknown origin) using EAIYAAPFKKK as substrate in the presence of ATP of 100 uM by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant wild type FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Fyn(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 5nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 6nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM184557(US9150579, B2)
Affinity DataKd: >6.20nMAssay Description:Binding affinity to PI3Kdelta (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611364(CHEMBL5280361)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50388180(CHEMBL2057912)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of recombinant BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM161389(US9108973, 2 | US10124003, Ref. Ex. Compound 3 | U...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human recombinant FGFR4 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611357(CHEMBL5286014)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611364(CHEMBL5280361)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of LYN (unknown origin) at 1 uM by kinase-profiling analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50611367(CHEMBL5277058)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of PI3Kdelta (unknown origin) at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM50611366(CHEMBL5287716)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) at 1 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50156383(CHEMBL3785951)
Affinity DataIC50: 12nMAssay Description:Inhibition of IGF-1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611356(CHEMBL5268867)
Affinity DataIC50: 13nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611357(CHEMBL5286014)
Affinity DataIC50: 13nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant FGFR1 in the presence of ATP at 0.16 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50258974(CHEMBL4090601)
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM194820(US9206184, 2 | US9206184, 1)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant FGFR3 in the presence of ATP at 0.8 uM measured after 1 hr by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50413999(CHEMBL475584 | CGP77675)
Affinity DataIC50: 20nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM50611358(CHEMBL5285282)
Affinity DataIC50: 23nMAssay Description:Inhibition of HER3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
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