Compile Data Set for Download or QSAR
Report error Found 63 Enz. Inhib. hit(s) with all data for entry = 50019708
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622097(CHEMBL5399590)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50552139(CHEMBL4790706)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50587871(CHEMBL5176610)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622096(CHEMBL5397107)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622098(CHEMBL5413646)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of IL-6 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of NO productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50155929(TAK-242 | CHEMBL225157)
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at TLR4 in mouse peritoneal macrophages assessed as inhibition of TNF-alpha productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50552134(CHEMBL4759149 | US11472815, Compound 22)
Affinity DataEC50:  4.90nMAssay Description:Agonist activity at TLR1/TLR2 in human THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM409969(2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622083(CHEMBL5435648)
Affinity DataEC50:  8nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50320082(1-(4-Amino-2-butyl-1H-imidazo-[4,5-c]quinolin-1-yl...)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622084(CHEMBL5415035)
Affinity DataEC50:  11nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622083(CHEMBL5435648)
Affinity DataEC50:  16nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50587871(CHEMBL5176610)
Affinity DataKd:  21nMAssay Description:Binding affinity to human TLR8 expressed in HEK-Blue hTLR8 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 4(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622092(VIZANTIN | Vizantin)
Affinity DataIC50: 53nMAssay Description:Inhibition of TLR4 in human HEK293T cells co-expressing MD-2 receptorMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622086(CHEMBL5400758)
Affinity DataEC50:  56nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50320072(1-Benzyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine...)
Affinity DataEC50:  59nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50587872(CHEMBL4553089)
Affinity DataIC50: 67nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM536358(US11242345, Example 70-B | CHEMBL5397718)
Affinity DataEC50:  85nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM409969(2-Amino-N,N-dipropyl-8-[6-(p-tolyl)-2,6-diazaspiro...)
Affinity DataEC50: >100nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622084(CHEMBL5415035)
Affinity DataEC50: >100nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50511993(CHEMBL4472879)
Affinity DataEC50:  110nMAssay Description:Agonist activity at TLR1/TLR2 in human THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50189516(9-benzyl-2-(2-methoxyethoxy)-8-oxoadenine | SM-360...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM393015(US9962388, Compound Example 21 | 2-butoxy-7-(4-(py...)
Affinity DataEC50:  160nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622085(CHEMBL5430530)
Affinity DataEC50:  180nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622086(CHEMBL5400758)
Affinity DataEC50:  190nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50587872(CHEMBL4553089)
Affinity DataKd:  220nMAssay Description:Binding affinity to human TLR8 expressed in HEK-Blue hTLR8 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50559849(Selgantolimod | Gs-9688)
Affinity DataEC50:  220nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50611681(CHEMBL5276534)
Affinity DataEC50:  260nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622087(CHEMBL5406749)
Affinity DataEC50:  270nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50503932(CHEMBL4443960)
Affinity DataEC50:  300nMAssay Description:Agonist activity at TLR2 (unknown origin) by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50552138(CHEMBL3935646)
Affinity DataKi:  410nMAssay Description:Binding affinity to TLR1/TLR2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50408506(CHEMBL5272163)
Affinity DataEC50:  450nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622085(CHEMBL5430530)
Affinity DataEC50:  550nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50511984(CHEMBL4581678)
Affinity DataEC50:  550nMAssay Description:Agonist activity at TLR1/TLR2 in human THP-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50552138(CHEMBL3935646)
Affinity DataIC50: 580nMAssay Description:Antagonist activity at TLR1/TLR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50552136(CHEMBL4795753)
Affinity DataIC50: 850nMAssay Description:Antagonist activity at TLR5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50408506(CHEMBL5272163)
Affinity DataEC50:  860nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50608583(CHEMBL5275095)
Affinity DataEC50:  1.57E+3nMAssay Description:Agonist activity at human TLR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM34883(ethyl 5-[2-oxidanylidene-2-[2,3,4-tris(oxidanyl)ph...)
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity at human TLR1/TLR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 7(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50240849(1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-ami...)
Affinity DataEC50:  2.12E+3nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 3(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622091(CHEMBL4303728)
Affinity DataKi:  2.96E+3nMAssay Description:Binding affinity to TLR3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622095(CHEMBL5423509)
Affinity DataIC50: 3.13E+3nMAssay Description:Antagonist activity at TLR5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 5(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622094(CHEMBL5436800)
Affinity DataIC50: 3.38E+3nMAssay Description:Antagonist activity at TLR5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 3(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50622091(CHEMBL4303728)
Affinity DataIC50: 3.44E+3nMAssay Description:Antagonist activity at TLR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50241029(1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quino...)
Affinity DataEC50:  4.50E+3nMAssay Description:Agonist activity at TLR8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 3(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50239681(CHEMBL4074408)
Affinity DataEC50:  4.80E+3nMAssay Description:Agonist activity at human TLR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
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