Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50022255
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type ROS1 (unknown origin) expressed in BaF3 cells incubated for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649924(CHEMBL5630153)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of recombinant human ROS1 G2032R mutant preincubated for 5 to 10 mins followed by substrate and ATP addition and measured after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649925(CHEMBL5624610 | US12435089, Example 10)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ROS1 G2032R mutant using KKKSPGEYVNIEFG as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649927(CHEMBL5630447)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ROS1 using KKKSPGEYVNIEFG as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649926(CHEMBL5625106)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ROS1 using KKKSPGEYVNIEFG as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649920(CHEMBL5631080)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of wild-type ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649925(CHEMBL5624610 | US12435089, Example 10)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ROS1 using KKKSPGEYVNIEFG as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649927(CHEMBL5630447)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ROS1 G2032R mutant using KKKSPGEYVNIEFG as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649926(CHEMBL5625106)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ROS1 G2032R mutant using KKKSPGEYVNIEFG as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649920(CHEMBL5631080)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649921(CHEMBL5630889)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of wild-type ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649922(CHEMBL5624939)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649924(CHEMBL5630153)
Affinity DataIC50: 0.840nMAssay Description:Inhibition of recombinant human ROS1 preincubated for 5 to 10 mins followed by substrate and ATP addition and measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649920(CHEMBL5631080)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROS1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649921(CHEMBL5630889)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649919(CHEMBL5624513)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of ALK (unknown origin) incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649923(CHEMBL5630160)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type ROS1 (unknown origin) expressed in BaF3 cells incubated for 4 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649923(CHEMBL5630160)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type ALK (unknown origin) expressed in BaF3 cells incubated for 4 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649924(CHEMBL5630153)
Affinity DataIC50: 2nMAssay Description:Inhibition of human ALK preincubated for 5 to 10 mins followed by substrate and ATP addition and measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of ROS1 G2032R mutant (unknown origin) expressed in BaF3 cells incubated for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649919(CHEMBL5624513)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of ROS1 (unknown origin) incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649922(CHEMBL5624939)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of wild-type ALK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649924(CHEMBL5630153)
Affinity DataIC50: 21nMAssay Description:Inhibition of human ALK L1196M/G1202R double mutant preincubated for 5 to 10 mins followed by substrate and ATP addition and measured after 60 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 27nMAssay Description:Inhibition of wild type ALK (unknown origin) expressed in BaF3 cells incubated for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)
Affinity DataIC50: 30nMAssay Description:Inhibition of wild-type ROS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649926(CHEMBL5625106)
Affinity DataIC50: 50nMAssay Description:Inhibition of human ALK5 using Casein as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649925(CHEMBL5624610 | US12435089, Example 10)
Affinity DataIC50: 50nMAssay Description:Inhibition of human ALK5 using Casein as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM50649927(CHEMBL5630447)
Affinity DataIC50: 50nMAssay Description:Inhibition of human ALK5 using Casein as substrate incubated for 120 mins in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Weifang Medical University

Curated by ChEMBL
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 64nMAssay Description:Inhibition of ALK G1202R mutant (unknown origin) expressed in BaF3 cells incubated for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed