Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50019871
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM269484(US10058534, 139)
Affinity DataEC50:  0.200nMAssay Description:Induction of ERalpha degradation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataEC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | WO-2014/19...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity to human wild type ERalpha ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50623924(Bexirestrant | BEXIRESTRANT)
Affinity DataIC50: 0.300nMAssay Description:Induction of wild type ERalpha degradation in human MCF cells by western blot assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataEC50:  0.400nMAssay Description:Induction of ERalpha degradation in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of ERalpha (246 to 595 residues) in doxycycline-induced human HEK293 cells incubated overnight by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | WO-2014/19...)
Affinity DataIC50: 0.5nMAssay Description:Binding affinity to human ERalpha D538G mutant ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | WO-2014/19...)
Affinity DataIC50: 0.600nMAssay Description:Binding affinity to human ERalpha Y537S mutant ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  0.640nMAssay Description:Binding affinity to wild type ERalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of ERbeta (261 to 500 residues) in doxycycline-induced human HEK293 cells incubated overnight by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM300969(US10961241, Example 36 | BDBM300970 | US10961241, ...)
Affinity DataEC50: <1nMAssay Description:Induction of ERalpha degradation in human MCF7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50623923(Vepdegestrant | Arv 471 | ARV-471 | ARV471 | VEPDE...)
Affinity DataEC50:  1nMAssay Description:Induction of ERalpha degradation in human MCF7 cellsMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to human wild type ERalpha ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of ERalpha (246 to 595 residues) in doxycycline-induced human HEK293 cells incubated overnight by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to ERalpha Y537S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataIC50: 3nMAssay Description:Induction of wild type ERalpha degradation in human MCF cells by high content imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataIC50: 3.30nMAssay Description:Binding affinity to human ERalpha D538G mutant ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)
Affinity DataIC50: 3.80nMAssay Description:Binding affinity to human ERalpha Y537S mutant ligand binding domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM269358((E)-3-(4-((2-(4-fluoro- 2-methylphenyl)-6- hydroxy...)
Affinity DataEC50:  4nMAssay Description:Induction of ERalpha degradation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor beta(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of ERbeta (261 to 500 residues) in doxycycline-induced human HEK293 cells incubated overnight by luciferase based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM443429(US10654866, Example 1A | US11117902, Example 1B | ...)
Affinity DataIC50: 9.60nMAssay Description:Induction of ERalpha Y537N mutant degradation in human MCF cells high content imaging assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM269278(US10058534, 2)
Affinity DataEC50:  31nMAssay Description:Induction of ERalpha degradation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed