Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50022437
TargetPurine nucleoside phosphorylase(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50323702([5'-3H]-Immuciline-H | CHEMBL1213652)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of PNP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin) using TK as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM19151(Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant HDAC6 using RHKKAc-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50204093(BAY 80-6946 | BAY-80-6946 | Copanlisib)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM309960(US9656996, Compound 10 | US20250145589, Example Li...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of N-terminal 6xHis-tagged recombinant full-length human PI3Kdelta expressed in baculovirus infected Sf21 insect cells by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition and measured after 1 hr by HTRF an...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EZH1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EZH1 (unknown origin) preincubated for 15 mins followed by addition of substrate measured after 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50457437(CHEBI:71223 | Folotyn | PDX | Pralatrexate)
Affinity DataKi:  13nMAssay Description:Binding affinity to Plasmodium falciparum DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM31089(DASATINIB)
Affinity DataKi:  16nMAssay Description:Inhibition of SRC (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 3(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-beta(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataEC50:  24nMAssay Description:Agonist activity at RXRbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-gamma(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at RXRgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US9758524, Example 6 | U...)
Affinity DataIC50: 30nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM31089(DASATINIB)
Affinity DataKi:  30nMAssay Description:Binding affinity to wild type human BCR-ABL1 using Tyr2 peptide as substrate assessed as inhibition constant Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50032675(4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaph...)
Affinity DataEC50:  33nMAssay Description:Agonist activity at RXRalpha (unknown origin) expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM19151(Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM19151(Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...)
Affinity DataIC50: 47nMAssay Description:Inhibition of human recombinant HDAC2 using AMC-K(Ac)GL as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25150(Belinostat | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)...)
Affinity DataIC50: 82nMAssay Description:Inhibition of human recombinant HDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM86734(CAS_220127-57-1 | NSC_0 | Gleevec)
Affinity DataIC50: 410nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM19151(Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...)
Affinity DataIC50: 510nMAssay Description:Inhibition of human recombinant HDAC4 using AMC-K(TFA)GL as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length BTK C481S mutant (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM194087(US9199997, 9 | US9879013, 19(2) | US20230364079, E...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of BTK (unknown origin) by Ambit kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed