Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50021476
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM18073(L-[2,3,4,5,6-3H]phenylalanine | (2S)-2-amino-3-phe...)
Affinity DataIC50: 0.0550nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641060(CHEMBL5569778)
Affinity DataKd:  0.915nMAssay Description:Binding affinity to human PKM2 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641057(CHEMBL5573729)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641071(CHEMBL5563349)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50455476(CHEBI:6922 | Micheliolide)
Affinity DataEC50:  6nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641069(CHEMBL5570128)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641073(CHEMBL5575015)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641070(CHEMBL5595787)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641076(CHEMBL5590701)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641065(CHEMBL5571324)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50597714(Mitapivat | Ag-348 | Pkr-in-1 | AG-348 | MITAPIVAT...)
Affinity DataEC50:  20nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641060(CHEMBL5569778)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50361557(CHEMBL1089334)
Affinity DataEC50:  30nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641064(CHEMBL5570684)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641075(CHEMBL5571984)
Affinity DataIC50: 36nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641061(CHEMBL5592948)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50022801(CHEMBL5274026)
Affinity DataEC50:  50nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 50nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641078(CHEMBL5565744)
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641080(CHEMBL5564291)
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641074(CHEMBL5595221)
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641077(CHEMBL5589630)
Affinity DataIC50: 68nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50455475(CHEMBL1085588)
Affinity DataEC50:  90nMAssay Description:Activation of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641058(CHEMBL5555427)
Affinity DataIC50: 115nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641067(CHEMBL5574197)
Affinity DataIC50: 117nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641079(CHEMBL5579653)
Affinity DataIC50: 214nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641062(CHEMBL5574969)
Affinity DataIC50: 219nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641072(CHEMBL5575541)
Affinity DataIC50: 346nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641059(CHEMBL5584079)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641063(CHEMBL5563968)
Affinity DataIC50: 1.58E+3nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641066(CHEMBL5571535)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50597715(CHEMBL4877010)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50641068(CHEMBL5565674)
Affinity DataIC50: 2.66E+3nMAssay Description:Inhibition of recombinant human PKM2 expressed in Escherichia coli preincubated for 30 mins followed by beta-NADH addition and measured over 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM50233673(cid_3718 | (+)-2-(4-(1-oxoisoindolin-2-yl)phenyl)p...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM21691(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridi...)
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A)

Curated by ChEMBL
LigandPNGBDBM60919(MLS001424114 | SMR000466371 | cid_5281718 | (2S,3R...)
Affinity DataIC50: 1.28E+5nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed