Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with all data for entry = 50019410
TargetSigma non-opioid intracellular receptor 1(Human)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619013BDBM50619013(CHEMBL5432062)
Affinity DataKi:  0.0130nMAssay Description:Binding affinity to S1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50035105BDBM50035105(Siramesine | Lu 28-179 | 1'-{4-[1-(4-fluorophenyl)...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-(+)-DTG from rat brain homogenate S2RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619002BDBM50619002(CHEMBL5406931)
Affinity DataKi:  0.760nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618996BDBM50618996(CHEMBL5424448)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619012BDBM50619012(CHEMBL5402927)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to S1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618999BDBM50618999(CHEMBL5430002)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618997BDBM50618997(CHEMBL5421889)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619005BDBM50619005(CHEMBL5437311)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21398BDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619004BDBM50619004(CHEMBL5433306)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619005BDBM50619005(CHEMBL5437311)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012855BDBM50012855(phenothiazine | cid_7108 | dibenzo-1,4-thiazine | ...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619003BDBM50619003(CHEMBL5406376)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50064172BDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity to S2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618994BDBM50618994(CHEMBL5434592)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619006BDBM50619006(CHEMBL5434285)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619001BDBM50619001(CHEMBL5437477)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618995BDBM50618995(CHEMBL5421208)
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50064172BDBM50064172(CHEMBL39900 | 1-benzylspiro[hexahydropyridine-4,2'...)
Affinity DataKi:  9.20nMAssay Description:Binding affinity to S1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618993BDBM50618993(CHEMBL5394434)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619004BDBM50619004(CHEMBL5433306)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618998BDBM50618998(CHEMBL5395079)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619000BDBM50619000(CHEMBL5396488)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619011BDBM50619011(CHEMBL5439863)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619002BDBM50619002(CHEMBL5406931)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619003BDBM50619003(CHEMBL5406376)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619012BDBM50619012(CHEMBL5402927)
Affinity DataKi:  12nMAssay Description:Binding affinity to S2R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618998BDBM50618998(CHEMBL5395079)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618999BDBM50618999(CHEMBL5430002)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618996BDBM50618996(CHEMBL5424448)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044725BDBM50044725(1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-methyl-piperaz...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50035105BDBM50035105(Siramesine | Lu 28-179 | 1'-{4-[1-(4-fluorophenyl)...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat brain homogenate S1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50009307BDBM50009307(Di-o-tolylguanidine | DITOLYLGUANIDINE)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619000BDBM50619000(CHEMBL5396488)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618997BDBM50618997(CHEMBL5421889)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619010BDBM50619010(CHEMBL5432579)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619006BDBM50619006(CHEMBL5434285)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619010BDBM50619010(CHEMBL5432579)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619001BDBM50619001(CHEMBL5437477)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618993BDBM50618993(CHEMBL5394434)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619008BDBM50619008(CHEMBL5420704)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 21398BDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619009BDBM50619009(CHEMBL5405188)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618995BDBM50618995(CHEMBL5421208)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50619005BDBM50619005(CHEMBL5437311)
Affinity DataIC50: 85nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618994BDBM50618994(CHEMBL5434592)
Affinity DataKi:  95nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619009BDBM50619009(CHEMBL5405188)
Affinity DataKi:  99nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50009307BDBM50009307(Di-o-tolylguanidine | DITOLYLGUANIDINE)
Affinity DataKi:  124nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50044725BDBM50044725(1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-methyl-piperaz...)
Affinity DataKi:  204nMAssay Description:Displacement of [3H]-(+)-DTG from rat liver homogenate S2R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
Universit£

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619008BDBM50619008(CHEMBL5420704)
Affinity DataKi:  209nMAssay Description:Displacement of [3H]-(+)-pentazocine from rat liver homogenate S1R incubated for 120 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
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