Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50020423
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590229(CHEMBL5197547 | US20240308980, Ex-1.4)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GST20-tagged human LRRK2 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM257207(US9493440, 51)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of GST-tagged truncated human LRRK2 G2019S mutant in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50398668(CHEMBL2178134 | US8802674, 256)
Affinity DataIC50: 1nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629806(CHEMBL5432835)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST20-tagged human LRRK2 using ERM as substrate measured after 90 mins in presence of ATP by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM538130(US11253516, Example 32)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human LRRK2 measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM538130(US11253516, Example 32)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human LRRK2 G2019S mutant measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629806(CHEMBL5432835)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST20-tagged human LRRK2 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human LRRK2 measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM482157(LRRK2-IN-1 | BDBM50379529 | US11370796, Compound L...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LRRK2 G2019S mutant in HEK293 cell lysate measured after 15 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM185558(US9156845, 217)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of GST-tagged human LRRK2 G2019S mutant expressed in Insect cell using ERM as substrate measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50436423(CHEMBL2397014)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human LRRK2 G2019S mutant measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50398668(CHEMBL2178134 | US8802674, 256)
Affinity DataIC50: 9nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590229(CHEMBL5197547 | US20240308980, Ex-1.4)
Affinity DataIC50: 10nMAssay Description:Inhibition of GST20-tagged human LRRK2 using ERM as substrate measured after 90 mins in presence of ATP by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM185558(US9156845, 217)
Affinity DataIC50: 13nMAssay Description:Inhibition of GST-tagged recombinant human LRRK2 expressed in Insect cell using ERM as substrate measured after 1 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM482157(LRRK2-IN-1 | BDBM50379529 | US11370796, Compound L...)
Affinity DataIC50: 13nMAssay Description:Inhibition of LRRK2 (1326 to 2527 residues) in HEK293 cell lysate measured after 15 mins in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629805(CHEMBL5410403)
Affinity DataIC50: 14nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590210(CHEMBL5205763 | US20240174679, Example 9-28)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST20-tagged human LRRK2 using ERM as substrate measured after 90 mins in presence of ATP by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629808(CHEMBL5438272)
Affinity DataIC50: 15nMAssay Description:PROTAC activity at CRBN/LRRK2 in mouse RAW264.7 cells assessed as reduction of protein degradation measured after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50: 17nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590224(CHEMBL5182935 | US20240308980, Ex-1.1)
Affinity DataIC50: 17nMAssay Description:Inhibition of GST20-tagged human LRRK2 using ERM as substrate measured after 90 mins in presence of ATP by lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human GST-tagged human LRRK2 (1326 to 2527 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590224(CHEMBL5182935 | US20240308980, Ex-1.1)
Affinity DataIC50: 21nMAssay Description:Inhibition of GST20-tagged human LRRK2 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629805(CHEMBL5410403)
Affinity DataIC50: 30nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human LRRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590224(CHEMBL5182935 | US20240308980, Ex-1.1)
Affinity DataIC50: 62nMAssay Description:Inhibition of CLK2 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629806(CHEMBL5432835)
Affinity DataIC50: 63nMAssay Description:Inhibition of CLK2 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629807(CHEMBL5413465)
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human G2019S LRRK2 expressed in Sf9 insect cells using H-RLGAWRFTTLRRARQGNTKQR-OH peptide as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant human GST-tagged human LRRK2 G2019S mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50425780(CHEMBL2316582)
Affinity DataIC50: 80nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM94893((6Z)-6-[2-azanyl-5-(2-methoxyphenyl)-1H-pyrimidin-...)
Affinity DataIC50: 89nMAssay Description:Inhibition of human LRRK2 G2019S mutant in presence of [gamma-33P]ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590210(CHEMBL5205763 | US20240174679, Example 9-28)
Affinity DataIC50: 119nMAssay Description:Inhibition of CLK2 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629807(CHEMBL5413465)
Affinity DataIC50: 146nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human LRRK2 expressed in Sf9 insect cells using H-RLGAWRFTTLRRARQGNTKQR-OH peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM294480(US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...)
Affinity DataIC50: 177nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629804(CHEMBL5437266)
Affinity DataIC50: 190nMAssay Description:Inhibition of mouse LRRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 192nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human LRRK2 G2019S mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590210(CHEMBL5205763 | US20240174679, Example 9-28)
Affinity DataIC50: 271nMAssay Description:Inhibition of GST20-tagged human LRRK2 by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629809(CHEMBL5395142)
Affinity DataIC50: 378nMAssay Description:Inhibition of human LRRK2 G2019S mutant using LRRKtide as substrate measured after 1 hrs by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM294480(US9586965, Cpd 3 | N-(3-((2-((3-fluoro-4-(4-methyl...)
Affinity DataIC50: 410nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50629809(CHEMBL5395142)
Affinity DataIC50: 424nMAssay Description:Inhibition of human LRRK2 using LRRKtide as substrate measured after 1 hrs by caliper mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50590229(CHEMBL5197547 | US20240308980, Ex-1.4)
Affinity DataIC50: 442nMAssay Description:Inhibition of CLK2 (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 600nMAssay Description:Inhibition of human LRRK2 I2020T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM185674(Rebastinib | 4-[4-[(5-tert-butyl-2-quinolin-6-ylpy...)
Affinity DataIC50: 737nMAssay Description:Inhibition of LRRK2 G2019S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed