Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50031823
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320009BDBM50320009((R)-1-((R)-cyclopropyl(o-tolyl)methoxy)-3-(2-methy...)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50161093BDBM50161093(CHEMBL2112075 | CHEMBL180672 | (R)-2-chloro-6-(2-h...)
Affinity DataIC50: 26nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320009BDBM50320009((R)-1-((R)-cyclopropyl(o-tolyl)methoxy)-3-(2-methy...)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320018BDBM50320018((2R)-1-(cyclopropyl(2-methoxyphenyl)methoxy)-3-(2-...)
Affinity DataIC50: 41nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320011BDBM50320011((2R)-1-(cyclopropyl(phenyl)methoxy)-3-(2-methyl-1-...)
Affinity DataIC50: 70nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320012BDBM50320012((2R)-1-(cyclobutyl(phenyl)methoxy)-3-(2-methyl-1-(...)
Affinity DataIC50: 74nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320019BDBM50320019((R)-1-((S)-cyclopropyl(o-tolyl)methoxy)-3-(2-methy...)
Affinity DataIC50: 83nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319998BDBM50319998((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 92nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320008BDBM50320008((2R)-1-(1-(2-methoxyphenyl)ethoxy)-3-(2-methyl-1-(...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320003BDBM50320003((2R)-1-(1-(2-chlorophenyl)ethoxy)-3-(2-methyl-1-(n...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320007BDBM50320007((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320000BDBM50320000((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 150nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320017BDBM50320017(2-(1-((R)-2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl...)
Affinity DataIC50: 160nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320002BDBM50320002((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320006BDBM50320006((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320013BDBM50320013((2R)-1-(cyclopentyl(phenyl)methoxy)-3-(2-methyl-1-...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320001BDBM50320001((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320005BDBM50320005((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319999BDBM50319999((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 210nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319990BDBM50319990((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320004BDBM50320004((2R)-1-(1-(3-chlorophenyl)ethoxy)-3-(2-methyl-1-(n...)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319994BDBM50319994((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320020BDBM50320020((S)-1-((R)-cyclopropyl(o-tolyl)methoxy)-3-(2-methy...)
Affinity DataIC50: 310nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319997BDBM50319997((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 360nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319995BDBM50319995((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 420nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319992BDBM50319992((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 440nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320009BDBM50320009((R)-1-((R)-cyclopropyl(o-tolyl)methoxy)-3-(2-methy...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320016BDBM50320016((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 540nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319996BDBM50319996((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 550nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319989BDBM50319989((R)-1-(benzyloxy)-3-(2-methyl-1-(naphthalen-2-yl)p...)
Affinity DataIC50: 560nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320010BDBM50320010((2R)-1-(2,2-dimethyl-1-phenylpropoxy)-3-(2-methyl-...)
Affinity DataIC50: 570nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320014BDBM50320014((2R)-1-(cyclohexyl(phenyl)methoxy)-3-(2-methyl-1-(...)
Affinity DataIC50: 610nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320015BDBM50320015((R)-1-(benzhydryloxy)-3-(2-methyl-1-(naphthalen-2-...)
Affinity DataIC50: 730nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320021BDBM50320021((S)-1-((S)-cyclopropyl(o-tolyl)methoxy)-3-(2-methy...)
Affinity DataIC50: 760nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319993BDBM50319993((2R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylami...)
Affinity DataIC50: 810nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319991BDBM50319991((R)-1-(2-methyl-1-(naphthalen-2-yl)propan-2-ylamin...)
Affinity DataIC50: 2.24E+3nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetExtracellular calcium-sensing receptor(Human)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50319988BDBM50319988((R)-2-hydroxy-3-(2-methyl-1-(naphthalen-2-yl)propa...)
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human CaSR expressed in rat PC12 cells transfected with zif promoter/luciferase by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed