Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 50046881
LigandChemical structure of BindingDB Monomer ID 50134989BDBM50134989(CHEMBL3746640)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134989BDBM50134989(CHEMBL3746640)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu-ADR matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134978BDBM50134978(CHEMBL3747294)
Affinity DataIC50: 10nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134968BDBM50134968(CHEMBL3746569)
Affinity DataIC50: 11nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134971BDBM50134971(CHEMBL3747066)
Affinity DataIC50: 12nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 104963BDBM104963(CHEMBL507361 | US8575391, Q | US11147816, PD032590...)
Affinity DataIC50: 13nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134976BDBM50134976(CHEMBL3746736)
Affinity DataIC50: 13nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50135016BDBM50135016(CHEMBL3747047)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134925BDBM50134925(CHEMBL2376666)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50134986BDBM50134986(CHEMBL3746559)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134927BDBM50134927(CHEMBL3747136)
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134973BDBM50134973(CHEMBL3746467)
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134938BDBM50134938(CHEMBL3747256)
Affinity DataIC50: 15nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134939BDBM50134939(CHEMBL3747359)
Affinity DataIC50: 18nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134926BDBM50134926(CHEMBL2376663)
Affinity DataIC50: 21nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134989BDBM50134989(CHEMBL3746640)
Affinity DataIC50: 21nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134996BDBM50134996(CHEMBL3746031)
Affinity DataIC50: 22nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50135003BDBM50135003(CHEMBL3746103)
Affinity DataIC50: 28nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 31nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50134965BDBM50134965(CHEMBL2376667)
Affinity DataIC50: 32nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134940BDBM50134940(CHEMBL3746537)
Affinity DataIC50: 32nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134969BDBM50134969(CHEMBL3746923)
Affinity DataIC50: 37nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134961BDBM50134961(CHEMBL3746142)
Affinity DataIC50: 81nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134970BDBM50134970(CHEMBL3747516)
Affinity DataIC50: 83nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134928BDBM50134928(CHEMBL3747368)
Affinity DataIC50: 94nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134962BDBM50134962(CHEMBL3746158)
Affinity DataIC50: 107nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134929BDBM50134929(CHEMBL3746516)
Affinity DataIC50: 118nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134937BDBM50134937(CHEMBL3746203)
Affinity DataIC50: 127nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134930BDBM50134930(CHEMBL3747610)
Affinity DataIC50: 262nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134932BDBM50134932(CHEMBL3745994)
Affinity DataIC50: 345nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134964BDBM50134964(CHEMBL3747708)
Affinity DataIC50: 379nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134961BDBM50134961(CHEMBL3746142)
Affinity DataIC50: 500nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134925BDBM50134925(CHEMBL2376666)
Affinity DataIC50: 530nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134933BDBM50134933(CHEMBL3747637)
Affinity DataIC50: 592nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134938BDBM50134938(CHEMBL3747256)
Affinity DataIC50: 700nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134939BDBM50134939(CHEMBL3747359)
Affinity DataIC50: 700nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134941BDBM50134941(CHEMBL3747496)
Affinity DataIC50: 899nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134960BDBM50134960(CHEMBL3746690)
Affinity DataIC50: 941nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134965BDBM50134965(CHEMBL2376667)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50134935BDBM50134935(CHEMBL3746213)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of MEK1 (unknown origin) using biotinylated ERK1 as substrate incubated for 2 hrs by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134996BDBM50134996(CHEMBL3746031)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134969BDBM50134969(CHEMBL3746923)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of MEK1 in human HeLa-MaTu-ADR matched pair cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134928BDBM50134928(CHEMBL3747368)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134986BDBM50134986(CHEMBL3746559)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134925BDBM50134925(CHEMBL2376666)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human carbonic anhydrase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134989BDBM50134989(CHEMBL3746640)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134929BDBM50134929(CHEMBL3746516)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Bayer Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50134968BDBM50134968(CHEMBL3746569)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2017
Entry Details Article
PubMed