Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 891
LigandPNGBDBM297395(US10112968, Compound D16)
Affinity DataKi:  0.300nM Kd:  0.0100nM Kon:  0.000300M-1s-1 Koff:  3.00E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandPNGBDBM297391(US10112968, Compound A5 | (2R,3R,4S,5R)-2-(6-amino...)
Affinity DataIC50: 0.590nMAssay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandPNGBDBM297390(US10112968, Compound A3 | (2R,3R,4S,5R)-2-(6-amino...)
Affinity DataIC50: 0.730nMAssay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandPNGBDBM297389(US10112968, Compound A2 | (2R,3R,4S,5R)-2-(6-amino...)
Affinity DataIC50: 0.740nMAssay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandPNGBDBM297394(US10112968, Compound C118)
Affinity DataKi:  13nM Kd:  1.70nM Kon:  0.0200M-1s-1 Koff:  1.20E+7s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandPNGBDBM297392(US10112968, Compound SAH)
Affinity DataKi:  320nM Kd:  71nM Kon:  0.100M-1s-1 Koff:  1.40E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent

LigandPNGBDBM297393(US10112968, Compound C94)
Affinity DataKi:  845nM Kd:  167nM Kon:  0.200M-1s-1 Koff:  1.20E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2019
Entry Details
US Patent