Compile Data Set for Download or QSAR
maximum 50k data
Found 196 Enz. Inhib. hit(s) with all data for entry = 9323
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458308((R)-3-fluoro-N-(6-fluoropyridin-2-yl)-4-methyl-5-(...)
Affinity DataIC50:  2nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458321((R)-3-fluoro-4-methyl-5-((1-(1-phenylethyl)piperid...)
Affinity DataIC50:  2nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458294((R)-4-methyl-5-((1-(1-phenylethyl)piperidin-4-yl)o...)
Affinity DataIC50:  7nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458320((R)-3-fluoro-N-(6-fluoropyridin-2-yl)-4-methyl-5-(...)
Affinity DataIC50:  7nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458293((R)-4-methyl-5-(methyl(1-(1-phenylethyl)piperidin-...)
Affinity DataIC50:  10nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458305(3-fluoro-5-((1-(2-fluorobenzyl)piperidin-4-yl)(met...)
Affinity DataIC50:  19nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458309(5-((1-benzylpiperidin-4-yl)(methyl)amino)-3-fluoro...)
Affinity DataIC50:  20nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458318(4-((1-benzylpiperidin-4-yl)(methyl)amino)-5-chloro...)
Affinity DataIC50:  24nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458315(5-((1-benzylpiperidin-4-yl)oxy)-4-methyl-N-(thiazo...)
Affinity DataIC50:  24nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458339(5-((1-benzylpiperidin-4-yl)(methyl)amino)-N-(thiaz...)
Affinity DataIC50:  26nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458337(4-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50:  29nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458297(4-((1-benzylpiperidin-4-yl)(methyl)amino)-N-(6-flu...)
Affinity DataIC50:  35nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458324((R)-N-(6-fluoropyridin-2-yl)-4-methyl-5-(methyl(1-...)
Affinity DataIC50:  38nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458335(4-(((1R,5S,8s)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50:  38nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458296(5-((1-benzylpiperidin-4-yl)(methyl)amino)-3-fluoro...)
Affinity DataIC50:  40nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458314(US10752623, Example 34)
Affinity DataIC50:  53nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458295(5-((1-benzylpiperidin-4-yl)(methyl)amino)-4-methyl...)
Affinity DataIC50:  56nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458341(5-((1-(3-chlorobenzyl)piperidin-4-yl)(methyl)amino...)
Affinity DataIC50:  61nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458340(5-((1-(2,5-difluorobenzyl)piperidin-4-yl)(methyl)a...)
Affinity DataIC50:  67nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458299(5-((1-(2-fluorobenzyl)piperidin-4-yl)(methyl)amino...)
Affinity DataIC50:  72nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458313(5-((1-(3-fluorobenzyl)piperidin-4-yl)(methyl)amino...)
Affinity DataIC50:  75nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458304((R)-5-((1-(1-(2-fluorophenyl)ethyl)piperidin-4-yl)...)
Affinity DataIC50:  81nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458323((R)-N-(6-fluoropyridin-2-yl)-5-methyl-6-((1-(1-phe...)
Affinity DataIC50:  85nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458263((S)-5-((1-((2-isopropylthiazol-4-yl)methyl)pyrroli...)
Affinity DataIC50:  87nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458292((R)-N-(6-fluoropyridin-2-yl)-5-methyl-6-(methyl(1-...)
Affinity DataIC50:  90nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458342(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50:  96nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458135((S)-5-((1-benzylpyrrolidin-3-yl)(methyl)amino)-N-(...)
Affinity DataIC50:  105nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458301(5-((1-benzylpiperidin-4-yl)(methyl)amino)-N-(6-flu...)
Affinity DataIC50:  110nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458114((S)-5-((1-benzylpyrrolidin-3-yl)(methyl)amino)-4-m...)
Affinity DataIC50:  110nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nav's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458306((S)-5-((1-benzylpyrrolidin-3-yl)(methyl)amino)-3-f...)
Affinity DataIC50:  115nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458307((S)-3-fluoro-5-((1-(2-fluorobenzyl)pyrrolidin-3-yl...)
Affinity DataIC50:  115nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458336(4-((1-benzylpiperidin-4-yl)(methyl)amino)-5-ethyl-...)
Affinity DataIC50:  131nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458317(5-((1-benzylpiperidin-4-yl)oxy)-N-(6-fluoropyridin...)
Affinity DataIC50:  148nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458319((S)-3-fluoro-5-((1-(2-fluorobenzyl)pyrrolidin-3-yl...)
Affinity DataIC50:  173nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458261((S)-5-((1-(3-fluorobenzyl)pyrrolidin-3-yl)(methyl)...)
Affinity DataIC50:  195nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458289((S)-5-((1-(2,5-difluorobenzyl)pyrrolidin-3-yl)(met...)
Affinity DataIC50:  195nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458343(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50:  213nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458344(5-((1-benzylpiperidin-4-yl)(methyl)amino)-3-fluoro...)
Affinity DataIC50:  217nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458300(5-((1-(2-fluorobenzyl)piperidin-4-yl)(methyl)amino...)
Affinity DataIC50:  220nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458334(5-(((1R,5S,8r)-3-benzyl-3-azabicyclo[3.2.1]octan-8...)
Affinity DataIC50:  234nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458316(5-((1-benzylpiperidin-4-yl)oxy)-N-(6-fluoropyridin...)
Affinity DataIC50:  250nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458302(5-((1-(3-fluorobenzyl)piperidin-4-yl)(methyl)amino...)
Affinity DataIC50:  283nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458333((R)-5-chloro-6-(methyl(1-(1-phenylethyl)piperidin-...)
Affinity DataIC50:  294nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458329(6-((1-benzylpiperidin-4-yl)(methyl)amino)-5-chloro...)
Affinity DataIC50:  296nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458114((S)-5-((1-benzylpyrrolidin-3-yl)(methyl)amino)-4-m...)
Affinity DataIC50:  314nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458338(5-(((1R,3r,5S)-8-(2,5-difluorobenzyl)-8-azabicyclo...)
Affinity DataIC50:  343nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458265((S)-5-((1-((4-cydcopropylthiazol-2-yl)methyl)pyrro...)
Affinity DataIC50:  386nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458298((S)-5-((1-benzylpyrrolidin-3-yl)(methyl)amino)-N-(...)
Affinity DataIC50:  390nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458291(4-methyl-5-(methyl((S)-1-((R)-1-phenylethyl)pyrrol...)
Affinity DataIC50:  395nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM458310((S)-5-((1-benzylpyrrolidin-3-yl)amino)-N-(thiazol-...)
Affinity DataIC50:  411nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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