Compile Data Set for Download or QSAR
maximum 50k data
Found 147 Enz. Inhib. hit(s) with all data for entry = 9800
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402004(5-[[5-[4-[(1-isopropyl-4-piperidyl)amino]-2-methox...)
Affinity DataIC50:  0.00400nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402003(5-[[5-[4-[(1-ethyl-4-piperidyl)amino]-2-methoxy-ph...)
Affinity DataIC50:  0.00500nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402002(5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)amino]ph...)
Affinity DataIC50:  0.00700nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402035(5-[[5-[4-[(1-ethyl-4-piperidyl)methyl-methyl-amino...)
Affinity DataIC50:  0.00800nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402036(5-[[5-[4-[(isobutylamino)methyl]-2-methoxy-phenyl]...)
Affinity DataIC50:  0.0120nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401985(5-[[5-[4-[(3R)-4-ethyl-3-methyl-piperazin-1-yl]-2-...)
Affinity DataIC50:  0.0160nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401974(5-[[5-[2-methoxy-4-[(3R)-3-methylpiperazin-1-yl]ph...)
Affinity DataIC50:  0.0160nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401984(5-[[5-[4-[(3R)-3,4-dimethylpiperazin-1-yl]-2-metho...)
Affinity DataIC50:  0.0160nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402031(5-[[5-[4-[[(3R)-1-isopropylpyrrolidin-3-yl]oxymeth...)
Affinity DataIC50:  0.0190nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402030(5-[[5-[4-[[(3R)-1-ethylpyrrolidin-3-yl]oxymethyl]-...)
Affinity DataIC50:  0.0210nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402033(5-[[5-[4-[(1-ethyl-4-piperidyl)methyl]-2-methoxy-p...)
Affinity DataIC50:  0.0210nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402010(5-[[5-[2-methoxy-4-[(2R)-4-ethylmorpholin-2-yl]phe...)
Affinity DataIC50:  0.0220nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401957(5-[[5-[2-methoxy-4-(1-methylazetidin-3-yl)phenyl]-...)
Affinity DataIC50:  0.0220nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402018(5-[[5-[4-[[(2S)-1-ethylpyrrolidin-2-yl]methoxy]-2-...)
Affinity DataIC50:  0.0230nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402020(5-[[5-[4-[(cyclopropylmethylamino)methyl]-2-methox...)
Affinity DataIC50:  0.0250nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401906(5-[[5-[2-methoxy-4-[(tetrahydropyran-4-ylamino)met...)
Affinity DataIC50:  0.0260nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401914(5-[[5-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]...)
Affinity DataIC50:  0.0260nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402034(5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl]-2-metho...)
Affinity DataIC50:  0.0260nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402009(5-[[5-[2-methoxy-4-[(2R)-4-methylmorpholin-2-yl]ph...)
Affinity DataIC50:  0.0270nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402029(5-[[5-[4-[[(3S)-1-isopropylpyrrolidin-3-yl]oxymeth...)
Affinity DataIC50:  0.0270nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402038(5-[[5-[4-[(1-isopropyl-4-piperidyl)methyl-methyl-a...)
Affinity DataIC50:  0.0310nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401904(5-[5-(4-{[(1-cyclopropane-carbonyl-piperidin-4-ylm...)
Affinity DataIC50:  0.0340nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402028(5-[[5-[4-[[(3S)-1-ethylpyrrolidin-3-yl]oxymethyl]-...)
Affinity DataIC50:  0.0410nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402000(5-[[5-[4-[(1-ethyl-4-piperidyl)methylamino]-2-meth...)
Affinity DataIC50:  0.0430nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402017(5-[[5-[4-[[(2R)-1-isopropylpyrrolidin-2-yl]methoxy...)
Affinity DataIC50:  0.0440nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402019(5-[[5-[4-[[(2S)-1-isopropylpyrrolidin-2-yl]methoxy...)
Affinity DataIC50:  0.0460nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401903(5-{5-[2-methoxy-4-(1-methyl-piperidin-4-yl)-phenyl...)
Affinity DataIC50:  0.0480nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402027(5-[[5-[4-(4-isopropylpiperazin-1-yl)-2-fluoro-6-me...)
Affinity DataIC50:  0.0480nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401981(5-[[5-[2-methoxy-4-[1-(2-methoxyethyl)-4-piperidyl...)
Affinity DataIC50:  0.0510nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401955(5-[[5-[2-methoxy-4-[[methyl(tetrahydropyran-4-yl)a...)
Affinity DataIC50:  0.0520nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401992(5-[[5-[4-[[isopropyl(methyl)amino]methyl]-2-methox...)
Affinity DataIC50:  0.0530nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402026(5-[[5-[4-(4-ethylpiperazin-1-yl)-2-fluoro-6-methox...)
Affinity DataIC50:  0.0530nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM490847(5-[[5-(2-methoxy-4-piperazin-1-yl- phenyl)-1H-pyra...)
Affinity DataIC50:  0.0540nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402025(5-[[5-[4-[(1-isopropyl-4-piperidyl)oxy]-2-methoxy-...)
Affinity DataIC50:  0.0540nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401993(5-[[5-[2-methoxy-4-(pyrrolidin-1-ylmethyl)phenyl]-...)
Affinity DataIC50:  0.0550nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402016(5-[[5-[4-[[(2R)-1-ethylpyrrolidin-2-yl]methoxy]-2-...)
Affinity DataIC50:  0.0560nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401900(5-(5-{4-[(4-fluoro-benzylamino)-methyl]-2-methoxy-...)
Affinity DataIC50:  0.0580nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401982(5-[[5-[4-(ethylaminomethyl)-2-methoxy-phenyl]-1H-p...)
Affinity DataIC50:  0.0580nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401979(5-[[5-[4-(1-ethyl-3-fluoro-4-piperidyl)-2-methoxy-...)
Affinity DataIC50:  0.0590nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401921(5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)methoxy]...)
Affinity DataIC50:  0.0680nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401949(5-[[5-[2-methoxy-4-(4-piperidyloxy)phenyl]-1H-pyra...)
Affinity DataIC50:  0.0710nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401951(5-[[5-[4-[(isopropylamino)methyl]-2-methoxy-phenyl...)
Affinity DataIC50:  0.0710nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401925(5-[[5-[2-methoxy-4-[(3S)-pyrrolidin-3-yl]oxy-pheny...)
Affinity DataIC50:  0.0740nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402008(5-[[5-(2-fluoro-6-methoxy-4-piperazin-1-yl-phenyl)...)
Affinity DataIC50:  0.0770nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401901(5-(5-{2-methoxy-4-[(2-morpholin-4-yl-ethylamino)-m...)
Affinity DataIC50:  0.0770nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401980(5-[[5-[4-(3-fluoro-1-isopropyl-4-piperidyl)-2-meth...)
Affinity DataIC50:  0.0790nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401999(5-[[5-[2-methoxy-4-[(1-methyl-4-piperidyl)methylam...)
Affinity DataIC50:  0.0810nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM402032(5-[[5-[4-(4-isobutylpiperazin-1-yl)-2-methoxy-phen...)
Affinity DataIC50:  0.0820nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401954(2-[4-[4-[3-[(5-cyanopyrazin-2-yl)amino]-1H-pyrazol...)
Affinity DataIC50:  0.0840nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sentinel Oncology

US Patent
LigandPNGBDBM401908(5-[[5-[2-methoxy-4-(2-morpholinoethylamino)phenyl]...)
Affinity DataIC50:  0.0850nMAssay Description:Base Reaction buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO Required co...More data for this Ligand-Target Pair
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In DepthDetails US Patent
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