Compile Data Set for Download or QSAR
Report error Found 373 Enz. Inhib. hit(s) with all data for entry = 9904
TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497901BDBM497901(6'-amino-6-((5R,8S)-3-(2,6- difluorophenyl)-9,9-di...)
Affinity DataIC50: 2.40nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497661BDBM497661((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...)
Affinity DataIC50: 2.70nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497898BDBM497898(2-amino-5-(4-((5R,8S)-3-(2,6- difluorophenyl)-9,9-...)
Affinity DataIC50: 2.90nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497573BDBM497573((2S)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 3nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497518BDBM497518(3-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 3nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497855BDBM497855((5R,8S)-8-(6-(3-(difluoromethyl)-1H- 1,2,4-triazol...)
Affinity DataIC50: 3.10nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497648BDBM497648(N-[[5-[6-[(1R,8R)-5-(2,6-difluorophenyl)- 11,11-di...)
Affinity DataIC50: 3.10nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497574BDBM497574((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...)
Affinity DataIC50: 3.20nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497658BDBM497658(2-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 3.30nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497586BDBM497586(3-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 3.5nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497527BDBM497527(2-methyl-2-[2-[6-[(1S,8R)-5-(2,6- difluorophenyl)-...)
Affinity DataIC50: 3.60nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497572BDBM497572((2R)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 3.70nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497726BDBM497726((2R)-1-[[5-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,...)
Affinity DataIC50: 3.90nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497519BDBM497519((2R)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 4nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497662BDBM497662((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...)
Affinity DataIC50: 4.10nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497657BDBM497657((2R)-2-methyl-3-[4-[6-[(1S,8R)-5-(2,6- difluorophe...)
Affinity DataIC50: 4.20nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497656BDBM497656((2S)-2-methyl-3-[4-[6-[(1S,8R)-5-(2,6- difluorophe...)
Affinity DataIC50: 4.20nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497554BDBM497554((1S,8R)-5-(2,6-difluorophenyl)-1-[6-[1-(2- ethylsu...)
Affinity DataIC50: 4.20nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497655BDBM497655(N-[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 4.20nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497559BDBM497559((2S)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 4.5nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497561BDBM497561((2R)-1-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 4.5nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497587BDBM497587(2-[3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,11-...)
Affinity DataIC50: 4.60nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497562BDBM497562((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...)
Affinity DataIC50: 4.60nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497730BDBM497730((2S)-3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 4.80nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497893BDBM497893(N-[6-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 4.80nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497869BDBM497869(5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dimeth...)
Affinity DataIC50: 4.90nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497553BDBM497553(2-[[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-di...)
Affinity DataIC50: 5nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497703BDBM497703(N-[[1-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-di...)
Affinity DataIC50: 5nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497627BDBM497627((2R)-3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 5nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497520BDBM497520((1S,8R)-5-(2,6-difluorophenyl)-11,11- dimethyl-1-[...)
Affinity DataIC50: 5.10nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497645BDBM497645(3-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 5.10nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497511BDBM497511((1S)-2-methyl-1-[2-[6-[(1R,8R)-5-(2,6- difluorophe...)
Affinity DataIC50: 5.10nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497659BDBM497659(N-(2-hydroxyethyl)-2-[4-[6-[(1S,8R)-5- (2,6-difluo...)
Affinity DataIC50: 5.20nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497729BDBM497729((2R)-3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 5.20nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497894BDBM497894(3-[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 5.20nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497647BDBM497647((2S)-2-hydroxy-N-[5-[6-[(1S,8R)-5-(2,6- difluoroph...)
Affinity DataIC50: 5.30nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497606BDBM497606((1S,8R)-5-(2,6-difluorophenyl)-1-[6-[1-(2- methoxy...)
Affinity DataIC50: 5.40nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497552BDBM497552(2,2,2-trifluoro-N-[(1R)-1-[2-[6-[(1S,8R)-5- (2,6-d...)
Affinity DataIC50: 5.40nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497715BDBM497715(2-[[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-di...)
Affinity DataIC50: 5.40nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497664BDBM497664((2S)-3-[4-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 5.40nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497581BDBM497581(3-[3-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 5.40nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497906BDBM497906((5R,8S)-8-(2-(3-(difluorophenyl)-1H- pyrazol-1-yl)...)
Affinity DataIC50: 5.5nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497525BDBM497525(ethyl N-[[2-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11...)
Affinity DataIC50: 5.60nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497579BDBM497579((2R)-2-[2-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 5.60nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497556BDBM497556(N-[5-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 5.70nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497790BDBM497790((1S)-1-[5-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,1...)
Affinity DataIC50: 5.70nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497644BDBM497644(2-[4-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dim...)
Affinity DataIC50: 5.70nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497707BDBM497707((2S)-1-[[5-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,...)
Affinity DataIC50: 5.80nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497575BDBM497575(2-[6-[(1S,8R)-5-(2,6-difluorophenyl)- 11,11-dimeth...)
Affinity DataIC50: 5.80nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 497510BDBM497510((1S)-2,2-difluoro-1-[2-[6-[(1R,8R)-5-(2,6- difluor...)
Affinity DataIC50: 5.80nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2021
Entry Details
US Patent

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