Compile Data Set for Download or QSAR
Report error Found 320 Enz. Inhib. hit(s) with all data for entry = 11083
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488431BDBM488431(1-(2-(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4- d]py...)
Affinity DataIC50: 1.02nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488414BDBM488414(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50: 2.20nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488365BDBM488365(2-(4-Amino-1-isopropyl-pyrazolo[3,4-d]pyrimidin- 3...)
Affinity DataIC50: 3.15nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488467BDBM488467(3-[3-Chloro-6-(1,3,4-thiadiazol-2-yl)-1H-indol-2- ...)
Affinity DataIC50: 4.15nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488468BDBM488468(1-Isopropyl-3-(6-oxazol-2-yl-1H-indol-2- yl)pyrazo...)
Affinity DataIC50: 4.19nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488464BDBM488464(2-[4-Amino-1-(3-hydroxycyclopentyl)-1H- pyrazolo[3...)
Affinity DataIC50: 4.25nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488369BDBM488369(2-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1- yl)...)
Affinity DataIC50: 4.53nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488366BDBM488366(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 4.57nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488449BDBM488449(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Affinity DataIC50: 4.73nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488407BDBM488407(2-[4-Amino-7-(propan-2-yl)pyrrolo[2,1- f][1,2,4]tr...)
Affinity DataIC50: 4.84nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488446BDBM488446(2-{4-Amino-1-cyclopentyl-1H-pyrazolo[3,4- d]pyrimi...)
Affinity DataIC50: 5.23nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488398BDBM488398(2-[4-Amino-1-(propan-2-yl)-1H-pyrazolo[4,3- c]pyri...)
Affinity DataIC50: 5.24nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488409BDBM488409(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Affinity DataIC50: 5.41nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488400BDBM488400(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 5.55nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488403BDBM488403(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 5.66nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488389BDBM488389(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 5.78nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488422BDBM488422(2-{4-Amino-1-cyclobutyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 5.78nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488403BDBM488403(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 5.83nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488469BDBM488469(3-(3-Chloro-6-oxazol-2-yl-1H-indol-2-yl)-1- isopro...)
Affinity DataIC50: 6.29nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488424BDBM488424(2-{4-Amino-1-cyclopentyl-1H-pyrazolo[3,4- d]pyrimi...)
Affinity DataIC50: 6.35nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488421BDBM488421(2-[4-Amino-7-chloro-1-(propan-2-yl)-1H- pyrazolo[4...)
Affinity DataIC50: 7.15nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488400BDBM488400(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 7.36nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488378BDBM488378(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 7.66nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488392BDBM488392(2-[4-Amino-1-(1-methylsulfonyl-4- piperidyl)pyrazo...)
Affinity DataIC50: 7.93nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488466BDBM488466(1-Isopropyl-3-[6-(1,3,4-thiadiazol-2-yl)-1H-indol-...)
Affinity DataIC50: 7.95nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488367BDBM488367(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 8.03nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488408BDBM488408(2-[4-Amino-7-(propan-2-yl)pyrrolo[2,1- f][1,2,4]tr...)
Affinity DataIC50: 8.31nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488464BDBM488464(2-[4-Amino-1-(3-hydroxycyclopentyl)-1H- pyrazolo[3...)
Affinity DataIC50: 8.48nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488463BDBM488463(2-[4-Amino-1-(oxan-4-yl)-1H-pyrazolo[3,4- d]pyrimi...)
Affinity DataIC50: 8.66nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488449BDBM488449(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Affinity DataIC50: 8.72nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488378BDBM488378(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 8.73nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488448BDBM488448(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 9.49nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488461BDBM488461(2-[4-Amino-1-(oxolan-3-yl)-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50: 9.88nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488425BDBM488425(2-(4-Amino-1-cyclohexyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 10nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488417BDBM488417(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 10.6nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 589104BDBM589104(US11548896, Example 82 | N-(2-{4-Amino-1-tert-buty...)
Affinity DataIC50: 11.1nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488456BDBM488456(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50: 13nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488367BDBM488367(2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3- d]pyrimidin...)
Affinity DataIC50: 13nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488373BDBM488373(2-(8-Amino-3-isopropyl-imidazo[1,5-a]pyrazin-1- yl...)
Affinity DataIC50: 13.2nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488454BDBM488454(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50: 13.8nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488428BDBM488428(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 14.2nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488383BDBM488383(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 14.3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488368BDBM488368(2-(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4- d]pyrim...)
Affinity DataIC50: 14.7nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488369BDBM488369(2-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1- yl)...)
Affinity DataIC50: 14.8nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488388BDBM488388(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 15.3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488409BDBM488409(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Affinity DataIC50: 16.2nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488365BDBM488365(2-(4-Amino-1-isopropyl-pyrazolo[3,4-d]pyrimidin- 3...)
Affinity DataIC50: 16.5nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488429BDBM488429(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50: 16.8nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488395BDBM488395(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 17.1nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 488361BDBM488361(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50: 17.2nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
US Patent

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