Compile Data Set for Download or QSAR
Report error Found 721 Enz. Inhib. hit(s) with all data for entry = 2630
TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808618BDBM808618(7-(2-fluoro-6-methyl-phenyl)-5-(4- piperidyloxy)is...)
Affinity DataKi:  0.0200nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808687BDBM808687(N-[7-(2-fluoro-6-methyl-phenyl)-5- [(1-methyl-4-pi...)
Affinity DataKi:  0.0270nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808598BDBM808598(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl...)
Affinity DataKi:  0.0400nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808704BDBM808704(6-(2-fluoro-6-methyl-phenyl)-N8-(1- methyl-4-piper...)
Affinity DataKi:  0.0400nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808581BDBM808581(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-pyrrolidin...)
Affinity DataKi:  0.0410nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808626BDBM808626(7-(2-fluoro-6-methyl-phenyl)-N5-(1- methyl-4-piper...)
Affinity DataKi:  0.0470nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808696BDBM808696(6-(2-Fluoro-6-methyl-phenyl)-N8-(4- piperidyl)quin...)
Affinity DataKi:  0.0470nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808595BDBM808595(N5-[(3S)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl...)
Affinity DataKi:  0.0490nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808579BDBM808579(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-pyrrolidin-...)
Affinity DataKi:  0.0500nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808568BDBM808568(7-(2-fluoro-6-methyl-phenyl)-N5-(4- piperidyl)isoq...)
Affinity DataKi:  0.0520nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808578BDBM808578(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-pyrrolidin...)
Affinity DataKi:  0.0520nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808673BDBM808673(7-(2-fluoro-6-methyl-phenyl)-5-[(1- methyl-4-piper...)
Affinity DataKi:  0.0540nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808689BDBM808689(7-(2-fluoro-6-methyl-phenyl)-5-(1- methyl-4-piperi...)
Affinity DataKi:  0.0550nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808601BDBM808601(7-(2-fluoro-6-methyl-phenyl)-5-[3- (methylamino)az...)
Affinity DataKi:  0.0560nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808705BDBM808705(3-amino-7-(2-fluoro-6-methyl- phenyl)-5-(4- piperi...)
Affinity DataKi:  0.0610nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808583BDBM808583(N5-(azetidin-3-ylmethyl)-7-(2-fluoro- 6-methyl-phe...)
Affinity DataKi:  0.0670nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808645BDBM808645(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2R)-1-methylpy...)
Affinity DataKi:  0.0690nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808709BDBM808709(6-(2-chloro-6-methyl-phenyl)-N8-(4- piperidyl)quin...)
Affinity DataKi:  0.0690nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808576BDBM808576(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-pyrrolidin-...)
Affinity DataKi:  0.0700nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808599BDBM808599(7-(2-fluoro-6-methyl-phenyl)-N3- methyl-N5-(4-pipe...)
Affinity DataKi:  0.0750nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808701BDBM808701(6-(2-chloro-6-methyl-phenyl)-N8-(1- methyl-4-piper...)
Affinity DataKi:  0.0780nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808656BDBM808656(5-[(3R)-3-(dimethylamino)-1- piperidyl]-7-(2-fluor...)
Affinity DataKi:  0.0820nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808598BDBM808598(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-3-piperidyl...)
Affinity DataKi:  0.0840nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808658BDBM808658(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-1-methyl-3-...)
Affinity DataKi:  0.0840nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808620BDBM808620(7-(2-fluoro-6-methyl-phenyl)-5-[(3R)- pyrrolidin-3...)
Affinity DataKi:  0.0890nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808657BDBM808657(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-1-methyl-3-...)
Affinity DataKi:  0.0910nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808650BDBM808650(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-1-methyl-2...)
Affinity DataKi:  0.0930nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808707BDBM808707(6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(1-methy...)
Affinity DataKi:  0.0940nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808589BDBM808589(N5-[(3R)-azepan-3-yl]-7-(2-fluoro-6- methyl-phenyl...)
Affinity DataKi:  0.0960nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808586BDBM808586(7-(2-fluoro-6-methyl-phenyl)-N5- [[(2S)-2- piperid...)
Affinity DataKi:  0.0970nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808641BDBM808641(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-1-methylpyr...)
Affinity DataKi:  0.0970nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808640BDBM808640(7-(2-fluoro-6-methyl-phenyl)-N5-(1- methylazetidin...)
Affinity DataKi:  0.100nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808582BDBM808582(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-3- piperid...)
Affinity DataKi:  0.101nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808651BDBM808651(5-[3-(dimethylamino)azetidin-1-yl]-7- (2-fluoro-6-...)
Affinity DataKi:  0.101nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808646BDBM808646(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3S)-1-methylpy...)
Affinity DataKi:  0.101nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808580BDBM808580(7-(2-fluoro-6-methyl-phenyl)-N5-(4- piperidylmethy...)
Affinity DataKi:  0.108nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808642BDBM808642(7-(2-fluoro-6-methyl-phenyl)-N5- [(3S)-1-methylpyr...)
Affinity DataKi:  0.111nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808591BDBM808591(7-(2-fluoro-6-methyl-phenyl)-5-[(3R)- 3-(methylami...)
Affinity DataKi:  0.113nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808621BDBM808621(7-(2-fluoro-6-methyl-phenyl)-N-(4- piperidyl)isoqu...)
Affinity DataKi:  0.116nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808644BDBM808644(7-(2-fluoro-6-methyl-phenyl)-N5-[(1- methylazetidi...)
Affinity DataKi:  0.117nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808618BDBM808618(7-(2-fluoro-6-methyl-phenyl)-5-(4- piperidyloxy)is...)
Affinity DataKi:  0.125nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808706BDBM808706(6-fluoro-7-(2-fluoro-6-methyl- phenyl)-N5-(4-piper...)
Affinity DataKi:  0.132nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808597BDBM808597(7-(2-fluoro-6-methyl-phenyl)-N5- [(3R)-3-piperidyl...)
Affinity DataKi:  0.132nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808634BDBM808634(7-(2-chloro-6-methyl-phenyl)-N5-(1- methyl-4-piper...)
Affinity DataKi:  0.133nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808575BDBM808575(N5-(azetidin-3-yl)-7-(2-fluoro-6- methyl-phenyl)is...)
Affinity DataKi:  0.143nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808629BDBM808629(5-[4-(dimethylamino)-1-piperidyl]-7- (2-fluoro-6-m...)
Affinity DataKi:  0.147nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808587BDBM808587(7-(2-fluoro-6-methyl-phenyl)-5-[4- (methylamino)-1...)
Affinity DataKi:  0.155nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808600BDBM808600(7-(2-fluoro-6-methyl-phenyl)-N3- isopropyl-N5-(4- ...)
Affinity DataKi:  0.155nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808619BDBM808619(5-(azetidin-3-yloxy)-7-(2-fluoro-6- methyl-phenyl)...)
Affinity DataKi:  0.168nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808699BDBM808699(N8-(1-Ethyl-4-piperidyl)-6-(2-fluoro- 6-methyl-phe...)
Affinity DataKi:  0.168nMAssay Description:SIK2, SIK1, SIK3, Abl, Scr, and EPHA2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 06-13nM of...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

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