Compile Data Set for Download or QSAR
Report error Found 146 Enz. Inhib. hit(s) with all data for entry = 11384
TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793239BDBM793239(32 5-((1-cyclopropyl-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 0.520nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793221BDBM793221(1 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)ur...)
Affinity DataIC50: 1.20nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793239BDBM793239(32 5-((1-cyclopropyl-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 1.51nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793243BDBM793243(38 N-hydroxy-5-((1-isopropyl-3-(4-(trifluoromethox...)
Affinity DataIC50: 1.70nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793238BDBM793238(31 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)u...)
Affinity DataIC50: 2.30nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793237BDBM793237(30 5-((1-cyclopropyl-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 2.5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 2.80nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793243BDBM793243(38 N-hydroxy-5-((1-isopropyl-3-(4-(trifluoromethox...)
Affinity DataIC50: 2.90nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793238BDBM793238(31 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)u...)
Affinity DataIC50: 3.10nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793237BDBM793237(30 5-((1-cyclopropyl-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 3.30nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 50507492BDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 3.40nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793221BDBM793221(1 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)ur...)
Affinity DataIC50: 3.5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793236BDBM793236(29 1-((3-bromopyrazolo[1,5-a]pyridin-5-yl)methyl)-...)
Affinity DataIC50: 3.60nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793245BDBM793245(49 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)t...)
Affinity DataIC50: 3.60nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 3.60nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793224BDBM793224(4 1-isopropyl-1-(pyrazolo[1,5-a]pyridin-5-ylmethyl...)
Affinity DataIC50: 3.70nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793256BDBM793256(61 (S)-5-((1-(sec-butyl)-3-(4-(trifluoromethoxy)ph...)
Affinity DataIC50: 3.70nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793221BDBM793221(1 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)ur...)
Affinity DataIC50: 3.80nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793245BDBM793245(49 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)t...)
Affinity DataIC50: 3.80nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793255BDBM793255(60 (R)-5-((1-(sec-butyl)-3-(4-(trifluoromethoxy)ph...)
Affinity DataIC50: 4nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793237BDBM793237(30 5-((1-cyclopropyl-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 4.10nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793254BDBM793254(59 5-((N-isopropyl-2-(4-(trifluoromethoxy)phenoxy)...)
Affinity DataIC50: 4.30nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 4.30nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793236BDBM793236(29 1-((3-bromopyrazolo[1,5-a]pyridin-5-yl)methyl)-...)
Affinity DataIC50: 4.30nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793236BDBM793236(29 1-((3-bromopyrazolo[1,5-a]pyridin-5-yl)methyl)-...)
Affinity DataIC50: 4.40nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793240BDBM793240(35 1-((3-cyanopyrazolo[1,5-a]pyridin-5-yl)methyl)-...)
Affinity DataIC50: 4.40nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793230BDBM793230(10 1-cyclobutyl-1-(pyrazolo[1,5-a]pyridin-5-ylmeth...)
Affinity DataIC50: 4.5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 4.5nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793230BDBM793230(10 1-cyclobutyl-1-(pyrazolo[1,5-a]pyridin-5-ylmeth...)
Affinity DataIC50: 5.30nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793235BDBM793235(28 1-((3-fluoropyrazolo[1,5-a]pyridin-5-yl)methyl)...)
Affinity DataIC50: 5.30nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793242BDBM793242(37 5-((1-(sec-butyl)-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 5.40nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793241BDBM793241(36 5-((1-isobutyl-3-(4-(trifluoromethoxy)phenyl)ur...)
Affinity DataIC50: 5.70nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793240BDBM793240(35 1-((3-cyanopyrazolo[1,5-a]pyridin-5-yl)methyl)-...)
Affinity DataIC50: 5.80nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793242BDBM793242(37 5-((1-(sec-butyl)-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 6nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793238BDBM793238(31 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)u...)
Affinity DataIC50: 6.10nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793249BDBM793249(53 5-((N-isopropyl-2-(4-isopropylphenoxy)acetamido...)
Affinity DataIC50: 6.10nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 50507492BDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 6.5nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793255BDBM793255(60 (R)-5-((1-(sec-butyl)-3-(4-(trifluoromethoxy)ph...)
Affinity DataIC50: 6.60nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793245BDBM793245(49 5-((1-isopropyl-3-(4-(trifluoromethoxy)phenyl)t...)
Affinity DataIC50: 6.60nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 139540BDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 6.70nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793262BDBM793262(65 5-((2-(4-(tert-butyl)phenoxy)-N-isopropylacetam...)
Affinity DataIC50: 6.70nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 7nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793239BDBM793239(32 5-((1-cyclopropyl-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 7.5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 50507492BDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50: 8.20nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 139540BDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 8.30nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 50550246BDBM50550246(Pf-06273340 | PF06273340 | US20260049077, Compound...)
Affinity DataIC50: 8.30nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793256BDBM793256(61 (S)-5-((1-(sec-butyl)-3-(4-(trifluoromethoxy)ph...)
Affinity DataIC50: 8.40nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793242BDBM793242(37 5-((1-(sec-butyl)-3-(4-(trifluoromethoxy)phenyl...)
Affinity DataIC50: 9.5nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 139540BDBM139540(US8889696, Staurosporine | US9051313, Staurosporin...)
Affinity DataIC50: 10nMAssay Description:Compounds (as well as stereoisomer(s) thereof and/or salt(s) thereof) were tested for CX3CR1 agonism in a cell based assay with fluorescent readout i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Baylor College of Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 793254BDBM793254(59 5-((N-isopropyl-2-(4-(trifluoromethoxy)phenoxy)...)
Affinity DataIC50: 10.1nMAssay Description:The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
7/1/2026
Entry Details
US Patent

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