Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 7624
TargetCatechol O-methyltransferase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206347(US9260413, Example 5)
Affinity DataIC50: 93nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50086215(CHEMBL3425743 | US9260413, Example 3)
Affinity DataIC50: 170nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206346(US9260413, Example 1)
Affinity DataIC50: 180nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206348(US9260413, Example 6)
Affinity DataIC50: 210nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent

TargetCatechol O-methyltransferase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM206349(US9260413, Example 8)
Affinity DataIC50: 590nMT: 2°CAssay Description:To determine IC50 values in the fluorescence polarization assay, solutions of test compounds were prepared and preincubated with COMT enzyme as state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2016
Entry Details
US Patent