Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 8335
TargetXanthine dehydrogenase/oxidase(Human)
TBA

US Patent
LigandPNGBDBM241947(US9428466, 4'-hydroxymerbarone)
Affinity DataIC50: 680nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetXanthine dehydrogenase/oxidase(Human)
TBA

US Patent
LigandPNGBDBM241948(US9428466, 4'-hydroxy-2-oxo-desthiomerbarone)
Affinity DataIC50: 1.06E+3nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
TBA

US Patent
LigandPNGBDBM46100(cid_100782 | 6-hydroxy-2,4-dioxo-N-phenyl-1H-pyrim...)
Affinity DataIC50: 1.20E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetXanthine dehydrogenase/oxidase(Human)
TBA

US Patent
LigandPNGBDBM50016784(CHEBI:40279 | BW-56158 | Zyloprim | Lopurin | BW-5...)
Affinity DataIC50: 2.13E+3nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
TBA

US Patent
LigandPNGBDBM241948(US9428466, 4'-hydroxy-2-oxo-desthiomerbarone)
Affinity DataIC50: 2.60E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 5.40E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
TBA

US Patent
LigandPNGBDBM241947(US9428466, 4'-hydroxymerbarone)
Affinity DataIC50: 9.40E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetXanthine dehydrogenase/oxidase(Human)
TBA

US Patent
LigandPNGBDBM241949(US9428466, Merbarone)
Affinity DataIC50: 2.74E+5nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetXanthine dehydrogenase/oxidase(Human)
TBA

US Patent
LigandPNGBDBM46100(cid_100782 | 6-hydroxy-2,4-dioxo-N-phenyl-1H-pyrim...)
Affinity DataIC50: 3.00E+5nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent