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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM507989
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11130759 Publication Date 9/28/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM507989
Synonyms:
4-((3R)-3-hydroxypyrrolidin-1-yl)-7- chloro-1-(2-methoxyphenyl)hydro- quinazolin-2-one | US11046691, Compound 151 | US11084798, Cpd No 151 | US11130759, Cpd. No. 151
Type:
Small organic molecule
Emp. Form.:
C19H18ClN3O3
Mol. Mass.:
371.818
SMILES:
COc1ccccc1-n1c2cc(Cl)ccc2c(nc1=O)N1CC[C@@H](O)C1 |r,wD:23.26,(-2.67,-4.12,;-1.33,-3.35,;,-4.12,;,-5.66,;1.33,-6.43,;2.67,-5.66,;2.67,-4.12,;1.33,-3.35,;1.33,-1.81,;,-1.04,;-1.33,-1.81,;-2.67,-1.04,;-4,-1.81,;-2.67,.5,;-1.33,1.27,;,.5,;1.33,1.27,;2.67,.5,;2.67,-1.04,;4,-1.81,;1.33,2.81,;2.58,3.72,;2.1,5.18,;.56,5.18,;-.34,6.43,;.09,3.72,)|
Structure:
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