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Target
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
Ligand
BDBM529918
Substrate
n/a
Meas. Tech.
Chelation-Enhanced Fluorescence (CHEF) Assay
Ki
36.0±n/a nM
Citation
 Bhattacharya, SK; Behenna, DC; Cameron, KO; Chen, P; Curto, JM; Freeman-Cook, KD; Jalaie, M; Kania, RS; Lian, Y; Nair, SK; Palmer, CL; Pettersson, MY; Rui, EY; Sammons, M; Yang, Q; Zhang, L Anti-proliferative agents for treating PAH US Patent  US11203594 Publication Date 12/21/2021 
Target
Name:
Cyclin-dependent kinase 6/G1/S-specific cyclin-D3
Synonyms:
CDK6/CycD3 | CDK6/D3 | CDK6/G1/S-specific cyclin D3 | CDK6/cyclin D3 | Cyclin-dependent kinase 6 | Cyclin-dependent kinase 6/G1/S-specific cyclin D3
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Component 2
Name:
G1/S-specific cyclin-D3
Synonyms:
CCND3 | CCND3_HUMAN
Type:
Enzyme
Mol. Mass.:
32521.90
Organism:
Homo sapiens (Human)
Description:
P30281
Residue:
292
Sequence:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
  
Inhibitor
Name:
BDBM529918
Synonyms:
US11203594, Example 28
Type:
Small organic molecule
Emp. Form.:
C24H33N5O5
Mol. Mass.:
471.5493
SMILES:
COCCN1CC2(CC(C2)n2c3nc(N[C@@H]4CCOC[C@H]4O)ncc3c(C)c(C(C)=O)c2=O)C1 |r|
Structure:
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