Reaction Details Report a problem with these data
Target
Low molecular weight phosphotyrosine protein phosphatase
Ligand
BDBM533100
Substrate
n/a
Meas. Tech.
LMPTP Primary Screening Protocol
IC50
500±n/a nM
Citation
 Bottini, N; Zou, J; Ganji, SR; Stanford, S; Pinkerton, A; Chung, TD; Hedrick, M; Ardecky, R Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof US Patent  US11220486 Publication Date 1/11/2022 
Target
Name:
Low molecular weight phosphotyrosine protein phosphatase
Synonyms:
3.1.3.2 | 3.1.3.48 | ACP1 | Adipocyte acid phosphatase | LMW-PTP | LMW-PTPase | LMWPTP | Low molecular weight cytosolic acid phosphatase | PPAC_HUMAN | Red cell acid phosphatase 1 | low molecular weight phosphotyrosine protein phosphatase isoform c
Type:
n/a
Mol. Mass.:
18042.81
Organism:
Homo sapiens (Human)
Description:
P24666
Residue:
158
Sequence:
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
  
Inhibitor
Name:
BDBM533100
Synonyms:
US10626094, Example I30 | US11220486, Compound I30 | {3-[(1-ethyl(4-piperidyl))methyl]phenyl}[2-(4- methoxyphenyl)(4-quinolyl)]amine
Type:
Small organic molecule
Emp. Form.:
C30H33N3O
Mol. Mass.:
451.6025
SMILES:
CCN1CCC(Cc2cccc(Nc3cc(nc4ccccc34)-c3ccc(OC)cc3)c2)CC1
Structure:
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