Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E-binding protein 1
Ligand
BDBM545661
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
3.80±n/a nM
Citation
 Sperry, S; Xiang, AX; Ernst, JT; Reich, SH; Sprengeler, PA; Shaghafi, M; Michels, T; Nilewski, C; Tran, CV; Packard, GK; Grubbs, A; Urkalan, K; Mukaiyama, T EIF4E-inhibiting compounds and methods US Patent  US11286268 Publication Date 3/29/2022 
Target
Name:
Eukaryotic translation initiation factor 4E-binding protein 1
Synonyms:
4EBP1_HUMAN | EIF4EBP1 | GFP-4EBP | GFP-4EBP1 | Green fluorescent protein-Eukaryotic initiation factor 4E (eIF4E) binding protein
Type:
Fusion protein
Mol. Mass.:
12578.35
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
118
Sequence:
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI
  
Inhibitor
Name:
BDBM545661
Synonyms:
US11286268, Compound 1152
Type:
Small organic molecule
Emp. Form.:
C31H26ClN5O5S
Mol. Mass.:
616.087
SMILES:
CO[C@H]1C[C@H](C1)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N |r,wD:4.6,2.1,(-10.28,-1.61,;-8.95,-.84,;-7.61,-1.61,;-7.21,-3.09,;-5.73,-2.69,;-6.12,-1.21,;-4.39,-3.47,;-4.39,-5,;-3.06,-5.78,;-1.72,-5,;-.39,-5.78,;.94,-5,;2.28,-5.78,;.94,-3.47,;2.28,-2.69,;2.28,-1.15,;3.61,-.38,;3.61,1.15,;2.28,1.93,;2.28,3.47,;3.61,4.23,;3.61,5.78,;4.94,3.47,;4.94,1.93,;6.28,1.15,;7.61,1.93,;8.95,1.15,;10.28,1.93,;8.95,-.38,;7.61,-1.15,;7.29,-2.66,;5.76,-2.82,;5.13,-1.42,;6.28,-.38,;8.32,-3.81,;7.85,-5.27,;9.83,-3.49,;-.39,-2.69,;-.39,-1.15,;-1.72,-3.47,;-3.06,-2.69,;-3.06,-1.15,;-3.06,.38,)|
Structure:
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