Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM561368
Substrate
n/a
Meas. Tech.
MAGL Inhibitory Activity
IC50
12.0±n/a nM
Citation
 Benz, J; Grether, U; Hornsperger, B; Kuhn, B; Richter, H; Kocer, B; O''Hara, F; Ritter, M; Tsuchiya, S; Collin, L; Johnson, SE; Bell, C Piperazine derivatives as MAGL inhibitors US Patent  US11390610 Publication Date 7/19/2022 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM561368
Synonyms:
US11390610, Example 197
Type:
Small organic molecule
Emp. Form.:
C25H29N5O2
Mol. Mass.:
431.5301
SMILES:
CC1(C)CCN(C1)c1ccc(cc1)C(=O)N1CCN(CC1)c1nc2ccccc2c(=O)[nH]1
Structure:
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