Reaction Details Report a problem with these data
Target
Transmembrane anterior posterior transformation protein 1 homolog
Ligand
BDBM575116
Substrate
n/a
Meas. Tech.
Assessing Antiviral Activity Against Human Cytomegalovirus (HCMV)
IC50
1128±n/a nM
Citation
 Remiszewski, S; Chiang, LW; Murphy, EA; Sun, Q; Kayser, F; Fink, SJ Broad spectrum antiviral compositions and methods US Patent  US11459321 Publication Date 10/4/2022 
Target
Name:
Transmembrane anterior posterior transformation protein 1 homolog
Synonyms:
CMVFR | Cytomegalovirus partial fusion receptor | TAPT1 | TAPT1_HUMAN
Type:
Protein
Mol. Mass.:
64270.48
Organism:
Human
Description:
Q6NXT6
Residue:
567
Sequence:
MAGVGDAAAPGEGGGGGVDGPQRDGRGEAEQPGGSGGQGPPPAPQLTETLGFYESDRRRERRRGRTELSLLRFLSAELTRGYFLEHNEAKYTERRERVYTCLRIPRELEKLMVFGIFLCLDAFLYVFTLLPLRVFLALFRLLTLPCYGLRDRRLLQPAQVCDILKGVILVICYFMMHYVDYSMMYHLIRGQSVIKLYIIYNMLEVADRLFSSFGQDILDALYWTATEPKERKRAHIGVIPHFFMAVLYVFLHAILIMVQATTLNVAFNSHNKSLLTIMMSNNFVEIKGSVFKKFEKNNLFQMSNSDIKERFTNYVLLLIVCLRNMEQFSWNPDHLWVLFPDVCMVIASEIAVDIVKHAFITKFNDITADVYSEYRASLAFDLVSSRQKNAYTDYSDSVARRMGFIPLPLAVLLIRVVTSSIKVQGILSYACVILFYFGLISLKVLNSIVLLGKSCQYVKEAKMEEKLSNPPATCTPGKPSSKSQNKCKPSQGLSTEENLSASITKQPIHQKENIIPLLVTSNSDQFLTTPDGDEKDITQDNSELKHRSSKKDLLEIDRFTICGNRID
  
Inhibitor
Name:
BDBM575116
Synonyms:
US11459321, Example 58
Type:
Small organic molecule
Emp. Form.:
C26H28N4O3S
Mol. Mass.:
476.591
SMILES:
O=C1OCCN1c1ccc(Cc2cnc(s2)N2CCc3ccc(cc3C2)N2CCOCC2)cc1
Structure:
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