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Target
Capsid protein
Ligand
BDBM580205
Substrate
n/a
Meas. Tech.
Anti-HBV Activity
EC50
79.0±n/a nM
Citation
 Kesteleyn, BR; Berke, JM; Coesemans, E; Grosse, SC; Jacoby, E; Jonckers, TH; Last, SJ; Verschueren, WG; Obringer, M; Doebelin, CC Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases US Patent  US11491148 Publication Date 11/8/2022 
Target
Name:
Capsid protein
Synonyms:
Core antigen
Type:
PROTEIN
Mol. Mass.:
26278.39
Organism:
Hepatitis B virus
Description:
ChEMBL_450484
Residue:
230
Sequence:
MIFVLGGCRHKLVCSPAPCNFFHLCLIISCSCPTVHASKLCLGWLWGMHIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
  
Inhibitor
Name:
BDBM580205
Synonyms:
US11491148, Compound C2
Type:
Small organic molecule
Emp. Form.:
C20H21F3N6O3
Mol. Mass.:
450.4143
SMILES:
Cc1cc(NC(=O)[C@H]2CCN(C2)C(=O)C(=O)NC2(CC(F)(F)C2)c2c[nH]nn2)ccc1F |r|
Structure:
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