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Found 79 with Last Name = 'kesteleyn' and Initial = 'br'
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514142(4-(3-((1-(4-chlorophenyl)-2-oxo-2-(6-(pentafluoro-...)
Affinity DataEC50:  0.640nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514144(US11053196, Compound 1A)
Affinity DataEC50:  1.30nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514145(US11053196, Compound 1B)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514146(4-(3-((1-(4-chlorophenyl)-2-(4-methyl-6-(trifluoro...)
Affinity DataEC50:  0.380nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514147(US11053196, Compound 2A)
Affinity DataEC50:  15nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514148(US11053196, Compound 2B)
Affinity DataEC50:  0.0780nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514178(4-(3-((1-(4-chlorophenyl)-2-(5-fluoro-6-(trifluoro...)
Affinity DataEC50:  0.560nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514179(US11053196, Compound 3A)
Affinity DataEC50:  36nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514183(US11053196, Compound 3B)
Affinity DataEC50:  0.120nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514194(4-(3-((1-(4-chlorophenyl)-2-(4-methyl-6-(trifluoro...)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514195(US11053196, Compound 4A)
Affinity DataEC50:  11nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514196(US11053196, Compound 4B)
Affinity DataEC50:  0.0570nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514197(4-(3-((1-(4-chlorophenyl)-2-(5-fluoro-6-(trifluoro...)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514198(US11053196, Compound 5A)
Affinity DataEC50:  2.30nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514199(US11053196, Compound 5B)
Affinity DataEC50:  0.120nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514200(4-(3-((1-(4-fluoro-2-methoxyphenyl)-2-oxo-2-(6-(tr...)
Affinity DataEC50:  0.630nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514201(US11053196, Compound 6A)
Affinity DataEC50:  250nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514202(US11053196, Compound 6B)
Affinity DataEC50:  0.390nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514203(US11053196, Compound 7A-D)
Affinity DataEC50:  0.100nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514204(US11053196, Compound 7B-D)
Affinity DataEC50:  16nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514205(4-(3-((1-(4-chloro-2-(2-hydroxyethoxy)phenyl)-2-ox...)
Affinity DataEC50:  0.150nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514206(4-(3-((1-(4-chlorophenyl)-2-(5-methoxy-6-(trifluor...)
Affinity DataEC50:  0.990nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514207(4-(3-((1-(4-chlorophenyl)-2-oxo-2-(2-(trifluoromet...)
Affinity DataEC50:  0.520nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514208(US11053196, Compound 10A)
Affinity DataEC50:  0.300nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514209(US11053196, Compound 10B)
Affinity DataEC50:  37nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514210(4-(3-((1-(4-chlorophenyl)-2-oxo-2-(6-((trifluorome...)
Affinity DataEC50:  0.280nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580191(US11491148, Compound C1 | US11491148, Compound C1$...)
Affinity DataEC50:  150nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580191(US11491148, Compound C1 | US11491148, Compound C1$...)
Affinity DataEC50:  270nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580205(US11491148, Compound C2)
Affinity DataEC50:  79nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580207(US11491148, Compound C3)
Affinity DataEC50:  11nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580218(US11491148, Compound C3')
Affinity DataEC50: >2.50E+3nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580226(US11491148, Compound C4)
Affinity DataEC50:  53nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580231(US11491148, Compound C5)
Affinity DataEC50:  40nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580245(US11491148, Compound C6)
Affinity DataEC50:  44nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580248(US11491148, Compound C6')
Affinity DataEC50:  2.91E+3nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580266(US11491148, Compound C7)
Affinity DataEC50:  100nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580284(US11491148, Compound C8)
Affinity DataEC50:  45nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580370(US11491148, Compound C9)
Affinity DataEC50:  204nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580397(US11491148, Compound C10)
Affinity DataEC50:  578nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580398(US11491148, Compound C11)
Affinity DataEC50:  1.50E+3nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580399(US11491148, Compound C12)
Affinity DataEC50:  1.29E+3nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580400(US11491148, Compound C13)
Affinity DataEC50:  61nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580401(US11491148, Compound C14)
Affinity DataEC50:  19nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580402(US11491148, Compound C15)
Affinity DataEC50:  14nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580406(US11491148, Compound C16)
Affinity DataEC50:  6nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580407(US11491148, Compound C17)
Affinity DataEC50:  10nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580408(US11491148, Compound C18)
Affinity DataEC50:  12nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580409(US11491148, Compound C19)
Affinity DataEC50:  19nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580410(US11491148, Compound C20)
Affinity DataEC50:  12nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCapsid protein(Hepatitis B virus)
Janssen Sciences Ireland

US Patent
LigandPNGBDBM580218(US11491148, Compound C3')
Affinity DataEC50: >2.50E+3nMAssay Description:The anti HBV activity was measured using the HepG2.117 cell line, a stable, inducible HBV producing cell line, which replicates HBV in the absence of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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