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Target
Capsid protein
Ligand
BDBM580370
Substrate
n/a
Meas. Tech.
Anti-HBV Activity
EC50
204±n/a nM
Citation
 Kesteleyn, BR; Berke, JM; Coesemans, E; Grosse, SC; Jacoby, E; Jonckers, TH; Last, SJ; Verschueren, WG; Obringer, M; Doebelin, CC Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases US Patent  US11491148 Publication Date 11/8/2022 
Target
Name:
Capsid protein
Synonyms:
Core antigen
Type:
PROTEIN
Mol. Mass.:
26278.39
Organism:
Hepatitis B virus
Description:
ChEMBL_450484
Residue:
230
Sequence:
MIFVLGGCRHKLVCSPAPCNFFHLCLIISCSCPTVHASKLCLGWLWGMHIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
  
Inhibitor
Name:
BDBM580370
Synonyms:
US11491148, Compound C9
Type:
Small organic molecule
Emp. Form.:
C20H19F5N6O3
Mol. Mass.:
486.3953
SMILES:
C[C@@H]1CN(C[C@H]1C(=O)Nc1cc(F)c(F)c(F)c1)C(=O)C(=O)NC1(CC(F)(F)C1)c1c[nH]nn1 |r|
Structure:
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