Target

Ligand

Substrate

Meas. Tech.

Papain Inhibition Assay

Ki

430±n/a nM

Citation

 Löser, R; Schilling, K; Dimmig, E; Gütschow, M Interaction of papain-like cysteine proteases with dipeptide-derived nitriles. J Med Chem 48:7688-707 (2005) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Procathepsin L

Synonyms:

CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein

Type:

Enzyme

Mol. Mass.:

37557.19

Organism:

Homo sapiens (Human)

Description:

Purchased from Calbiochem (San Diego, CA).

Residue:

333

Sequence:

MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM20110

Synonyms:

dipeptide-derived nitrile, 31 | tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamate

Type:

Small organic molecule

Emp. Form.:

C18H22N4O3

Mol. Mass.:

342.3923

SMILES:

CC(C)(C)OC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC#N |r|

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM20128

Synonyms:

Z-Phe-Arg-NH-4-methylcoumarin-7-yl | Z-Phe-Arg-NHMec

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: