Target

Ligand

Substrate

Meas. Tech.

Thymidine Kinase Inhibition Assay

pH

7.5±n/a

Temperature

310.15±n/a K

Citation

 Manikowski, A; Verri, A; Lossani, A; Gebhardt, BM; Gambino, J; Focher, F; Spadari, S; Wright, GE Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo. J Med Chem 48:3919-29 (2005) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Thymidine kinase

Synonyms:

TK

Type:

Transferase

Mol. Mass.:

40915.49

Organism:

Human herpesvirus 1

Description:

O72346

Residue:

376

Sequence:

MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM21868

Synonyms:

2-amino-9-(4-hydroxybutyl)-6,9-dihydro-3H-purin-6-one | 9-(4-hydroxybutyl)guanine | CHEMBL258513 | HBG

Type:

Small organic molecule

Emp. Form.:

C9H13N5O2

Mol. Mass.:

223.2318

SMILES:

Nc1nc2n(CCCCO)cnc2c(=O)[nH]1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM21867

Synonyms:

[3H-methyl]TdR | [3H]thymidine

Type:

radiolabeled ligand

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: