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Target
Tyrosine-protein kinase SYK
Ligand
BDBM26409
Substrate
ZAP-70 Peptide Substrate
Meas. Tech.
Intracellular ZAP-70 Kinase Inhibition Assay
IC50
3300±n/a nM
Citation
 Hirabayashi, A; Mukaiyama, H; Kobayashi, H; Shiohara, H; Nakayama, S; Ozawa, M; Miyazawa, K; Misawa, K; Ohnota, H; Isaji, M Structure-activity relationship studies of 5-benzylaminoimidazo[1,2-c]pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors. Bioorg Med Chem 17:284-94 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM26409
Synonyms:
7-[(3,5-dimethoxyphenyl)amino]-5-{[(1S)-1-phenylethyl]amino}imidazo[1,2-a]pyrimidine-8-carboxamide | imidazo[1,2-c]pyrimidine-8-carboxamide, 10h
Type:
Small organic molecule
Emp. Form.:
C23H24N6O3
Mol. Mass.:
432.4751
SMILES:
COc1cc(Nc2nc(N[C@@H](C)c3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
ZAP-70 Peptide Substrate
Synonyms:
Syk Peptide Substrate
Type:
Peptide
Mol. Mass.:
1797.98
Organism:
n/a
Description:
n/a
Residue:
15
Sequence:
AEEEIYGEFEAKKKK