Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1 [S99G]
Ligand
BDBM54747
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)
IC50
50000±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay (2008)[AID] 
Target
Name:
Neutrophil cytosol factor 1 [S99G]
Synonyms:
NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44664.39
Organism:
Homo sapiens (Human)
Description:
gi_115298672
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM54747
Synonyms:
MLS000689387 | N-cyclopentyl-2-(3-keto-4,6-dimethyl-isothiazolo[5,4-b]pyridin-2-yl)acetamide | N-cyclopentyl-2-(4,6-dimethyl-3-oxidanylidene-[1,2]thiazolo[5,4-b]pyridin-2-yl)ethanamide | N-cyclopentyl-2-(4,6-dimethyl-3-oxo-2-isothiazolo[5,4-b]pyridinyl)acetamide | N-cyclopentyl-2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetamide | N-cyclopentyl-2-(4,6-dimethyl-3-oxoisothiazolo[5,4-b]pyridin-2(3H)-yl)acetamide | SMR000311186 | cid_4048808
Type:
Small organic molecule
Emp. Form.:
C15H19N3O2S
Mol. Mass.:
305.395
SMILES:
Cc1cc(C)c2c(n1)sn(CC(=O)NC1CCCC1)c2=O
Structure:
Search PDB for entries with ligand similarity: