Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM81670
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
94± 1e+1 nM
Citation
 Darkins, P; Gilmore, BF; Hawthorne, SJ; Healy, A; Moncrieff, H; McCarthy, N; McKervey, MA; Brömme, D; Pagano, M; Walker, B Synthesis of peptidyl ene diones: selective inactivators of the cysteine proteinases. Chem Biol Drug Des 69:170-9 (2007) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Human
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM81670
Synonyms:
Peptidyl ene diones, COOEt
Type:
Small organic molecule
Emp. Form.:
C25H28N2O6
Mol. Mass.:
452.4996
SMILES:
CCOC(=O)C=CC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r,w:6.6|
Structure:
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