Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM84499
Substrate
n/a
Meas. Tech.
Phosphatase Inhibition Assay
pH
6.5±0
Temperature
310.15±0 K
IC50
4.9e+3± 3e+3 nM
Citation
 Fürstner, A; Reinecke, K; Prinz, H; Waldmann, H The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors. Chembiochem 5:1575-9 (2004) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM84499
Synonyms:
2-(5-{1-[(2Z)-2H-pyrrol-2-ylidene]ethyl}furan-2-yl)-1H-pyrrole hydrochloride, 5 | CHEMBL1765359
Type:
Small organic molecule
Emp. Form.:
C14H12N2O
Mol. Mass.:
224.2579
SMILES:
C\C(=C1/C=CC=N1)c1ccc(o1)-c1ccc[nH]1 |c:3,5|
Structure:
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