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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50248892
Substrate
n/a
Meas. Tech.
ChEMBL_1679402 (CHEMBL4029679)
IC50
6.8±n/a nM
Citation
 Bataille, CJ; Brennan, MB; Byrne, S; Davies, SG; Durbin, M; Fedorov, O; Huber, KV; Jones, AM; Knapp, S; Liu, G; Nadali, A; Quevedo, CE; Russell, AJ; Walker, RG; Westwood, R; Wynne, GM Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family. Bioorg Med Chem 25:2657-2665 (2017) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50248892
Synonyms:
CHEMBL4074078
Type:
Small organic molecule
Emp. Form.:
C19H19N3OS3
Mol. Mass.:
401.569
SMILES:
O=C1NC(=S)S\C1=C/c1csc(n1)-c1ccc(CN2CCCCC2)cc1
Structure:
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