Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50008286
Substrate
n/a
Meas. Tech.
ChEBML_54603
Ki
0.017000±n/a nM
Citation
DeGraw, JI; Christie, PH; Colwell, WT; Sirotnak, FM Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin. J Med Chem 35:320-4 (1992) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_MOUSE | Dhfr
Type:
Enzyme
Mol. Mass.:
21608.82
Organism:
Mouse
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD
Inhibitor
Name:
BDBM50008286
Synonyms:
2-[4-(1,3-Diamino-7,8,9,10-tetrahydro-pyrimido[4,5-c]isoquinolin-8-yl)-benzoylamino]-pentanedioic acid | CHEMBL109229
Type:
Small organic molecule
Emp. Form.:
C23H24N6O5
Mol. Mass.:
464.4739
SMILES:
Nc1nc(N)c2c3CCC(Cc3cnc2n1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O