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Target
Proteasome subunit beta type-5
Ligand
BDBM50257327
Substrate
n/a
Meas. Tech.
ChEBML_1689794
Ki
3744±n/a nM
Citation
 LaMonte, GM; Almaliti, J; Bibo-Verdugo, B; Keller, L; Zou, BY; Yang, J; Antonova-Koch, Y; Orjuela-Sanchez, P; Boyle, CA; Vigil, E; Wang, L; Goldgof, GM; Gerwick, L; O'Donoghue, AJ; Winzeler, EA; Gerwick, WH; Ottilie, S Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem 60:6721-6732 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50257327
Synonyms:
CHEMBL4067938
Type:
Small organic molecule
Emp. Form.:
C26H47N3O5
Mol. Mass.:
481.6685
SMILES:
CCCCCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Structure:
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